3-(1-ethynyl)-4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenylpyridine

Base Information

Chemical Name:3-(1-ethynyl)-4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenylpyridine
CAS No.:135427-15-5
Molecular Formula:C₂₃H₂₀FN
Molecular Weight:329.417
Hs Code.:

Synonyms:3-(1-ethynyl)-4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenylpyridine

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Chemical Property of 3-(1-ethynyl)-4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenylpyridine

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Technology Process of 3-(1-ethynyl)-4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenylpyridine

There total 9 articles about 3-(1-ethynyl)-4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 135426-47-0
3-(2,2-Dibromoethenyl)-4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenylpyridine

: 135427-15-5
3-(1-ethynyl)-4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenylpyridine

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;
DOI:10.1021/jm00113a019

Reference yield:

: ammonium chloride

: 135426-74-3
(S)-4-[[[4-(4-Fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenyl-3-pyridinyl]ethynyl]hydroxyphosphinyl]-3-hydroxybutanoic acid, dilithium salt

: acetylene A

: 135427-15-5
3-(1-ethynyl)-4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenylpyridine

Guidance literature:: With n-butyllithium; In tetrahydrofuran;

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 135427-15-5
3-(1-ethynyl)-4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenylpyridine

Guidance literature:: Multi-step reaction with 7 steps

1: piperidine, HOAc / benzene / 22 h / Heating

2: 1.) LiN(TMS)2 / 1.) THF, -78 deg C, 1 h, 2.) THF, 1.5 h

3: 87 percent / NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

4: 92 percent / LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

5: oxalyl chloride, DMSO / CH₂Cl₂; tetrahydrofuran / 0.25 h / -78 °C

6: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

7: 93 percent / n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

With piperidine; lithium aluminium tetrahydride; n-butyllithium; copper diacetate; oxalyl dichloride; ammonium acetate; acetic acid; dimethyl sulfoxide; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane; acetic acid; benzene;
DOI:10.1021/jm00113a019