(Z)-N-(1-(2-chlorophenyl)-4-(triisopropylsilyl)but-1-en-3-yn-1-yl)acetamide

Base Information

• Chemical Name: (Z)-N-(1-(2-chlorophenyl)-4-(triisopropylsilyl)but-1-en-3-yn-1-yl)acetamide
• CAS No.: 1620165-40-3
• Molecular Formula: C₂₁H₃₀ClNOSi
• Molecular Weight: 376.014
• Mol file: 1620165-40-3.mol

Synonyms:(Z)-N-(1-(2-chlorophenyl)-4-(triisopropylsilyl)but-1-en-3-yn-1-yl)acetamide

Chemical Property of (Z)-N-(1-(2-chlorophenyl)-4-(triisopropylsilyl)but-1-en-3-yn-1-yl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-N-(1-(2-chlorophenyl)-4-(triisopropylsilyl)but-1-en-3-yn-1-yl)acetamide

There total 3 articles about (Z)-N-(1-(2-chlorophenyl)-4-(triisopropylsilyl)but-1-en-3-yn-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-[(triisopropylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one (181934-30-5) + 1-acetylamino-1-(2'-chlorophenyl)ethene (349537-53-7) → (Z)-N-(1-(2-chlorophenyl)-4-(triisopropylsilyl)but-1-en-3-yn-1-yl)acetamide (1620165-40-3)

Guidance literature:

With tris(acetonitrile)pentamethylcyclopentadienylrhodium(III) hexafluoroantimonate; Trimethylacetic acid; In acetone; at 20 ℃; for 12h;

DOI:10.1039/c4cc04072d

Reference yield:

1-(2-chlorophenyl)ethanone (2142-68-9) → (Z)-N-(1-(2-chlorophenyl)-4-(triisopropylsilyl)but-1-en-3-yn-1-yl)acetamide (1620165-40-3)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium acetate / methanol / 2 h / 60 °C

2: iron; acetic acid / toluene / 70 °C / Inert atmosphere

3: tris(acetonitrile)pentamethylcyclopentadienylrhodium(III) hexafluoroantimonate; Trimethylacetic acid / acetone / 12 h / 20 °C

With tris(acetonitrile)pentamethylcyclopentadienylrhodium(III) hexafluoroantimonate; hydroxylamine hydrochloride; sodium acetate; iron; acetic acid; Trimethylacetic acid; In methanol; acetone; toluene;

DOI:10.1039/c4cc04072d

Reference yield:

1-(2-chlorophenyl)ethanone oxime (7147-44-6) → (Z)-N-(1-(2-chlorophenyl)-4-(triisopropylsilyl)but-1-en-3-yn-1-yl)acetamide (1620165-40-3)

Guidance literature:

Multi-step reaction with 2 steps

1: iron; acetic acid / toluene / 70 °C / Inert atmosphere

2: tris(acetonitrile)pentamethylcyclopentadienylrhodium(III) hexafluoroantimonate; Trimethylacetic acid / acetone / 12 h / 20 °C

With tris(acetonitrile)pentamethylcyclopentadienylrhodium(III) hexafluoroantimonate; iron; acetic acid; Trimethylacetic acid; In acetone; toluene;

DOI:10.1039/c4cc04072d

upstream raw materials:

1-(2-chlorophenyl)ethanone

1-(2-chlorophenyl)ethanone oxime

1-[(triisopropylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one

1-acetylamino-1-(2'-chlorophenyl)ethene