1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylic acid

Base Information

Chemical Name:1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylic acid
CAS No.:1198591-51-3
Molecular Formula:C₂₉H₃₀N₂O₃
Molecular Weight:454.569
Hs Code.:

Synonyms:1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylic acid

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Chemical Property of 1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylic acid

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Technology Process of 1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylic acid

There total 8 articles about 1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1198592-19-6
methyl 1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate

: 1198591-51-3
1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylic acid

Guidance literature:: methyl 1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate; With sodium hydroxide; In tetrahydrofuran; methanol; for 3h; Heating; Reflux;

With water; In tetrahydrofuran; methanol; pH=1;

Reference yield:

: 860457-92-7
methyl 3-bromo-1H-indazole-6-carboxylate

: 1198591-51-3
1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: dmap / tetrahydrofuran / 16 h / 20 °C

2.1: caesium carbonate / Pd tetrakis / 1,2-dimethoxyethane; water / 22 h / Heating; Reflux

3.1: hydrogenchloride / ethyl acetate

4.1: caesium carbonate / acetonitrile / 2 h / Reflux

5.1: hydrazine hydrate / methanol / 16 h / 75 °C

6.1: HATU / tetrahydrofuran; N,N-dimethyl-formamide / 24 h / 20 °C

7.1: sodium hydroxide / tetrahydrofuran; methanol / 3 h / Heating; Reflux

7.2: pH 1

With hydrogenchloride; dmap; caesium carbonate; hydrazine hydrate; HATU; sodium hydroxide; Pd tetrakis; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 479552-81-3
3-bromoindole-1,6-dicarboxylic acid 1-tert-butyl ester 6-methyl ester

: 1198591-51-3
1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / Pd tetrakis / 1,2-dimethoxyethane; water / 22 h / Heating; Reflux

2.1: hydrogenchloride / ethyl acetate

3.1: caesium carbonate / acetonitrile / 2 h / Reflux

4.1: hydrazine hydrate / methanol / 16 h / 75 °C

5.1: HATU / tetrahydrofuran; N,N-dimethyl-formamide / 24 h / 20 °C

6.1: sodium hydroxide / tetrahydrofuran; methanol / 3 h / Heating; Reflux

6.2: pH 1

With hydrogenchloride; caesium carbonate; hydrazine hydrate; HATU; sodium hydroxide; Pd tetrakis; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;