methyl 1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate

Base Information

Chemical Name:methyl 1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate
CAS No.:1198592-19-6
Molecular Formula:C₃₀H₃₂N₂O₃
Molecular Weight:468.596
Hs Code.:

Synonyms:methyl 1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate

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Chemical Property of methyl 1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate

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Technology Process of methyl 1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate

There total 8 articles about methyl 1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 536-66-3
p-isopropylbenzoic acid

: 1198592-18-5
methyl 1-(4-aminobutyl)-3-phenyl-1H-indole-6-carboxylate

: 1198592-19-6
methyl 1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate

Guidance literature:: With HATU; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 1198592-18-5
methyl 1-(4-aminobutyl)-3-phenyl-1H-indole-6-carboxylate

: 21900-62-9
p-isopropylbenzoyl chloride

: 1198592-19-6
methyl 1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1.5h;

Reference yield:

: 479552-81-3
3-bromoindole-1,6-dicarboxylic acid 1-tert-butyl ester 6-methyl ester

: 1198592-19-6
methyl 1-[4-({[4-(1-methylethyl)phenyl]carbonyl}amino)butyl]-3-phenyl-1H-indole-6-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / Pd tetrakis / 1,2-dimethoxyethane; water / 22 h / Heating; Reflux

2: hydrogenchloride / ethyl acetate

3: caesium carbonate / acetonitrile / 2 h / Reflux

4: hydrazine hydrate / methanol / 16 h / 75 °C

5: triethylamine / dichloromethane / 1.5 h / 20 °C

With hydrogenchloride; caesium carbonate; hydrazine hydrate; triethylamine; Pd tetrakis; In methanol; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; acetonitrile;