Technology Process of methyl 2-[4-(bromomethyl)-2-fluorophenyl]propanoate
There total 11 articles about methyl 2-[4-(bromomethyl)-2-fluorophenyl]propanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile);
In
tetrachloromethane;
for 2h;
Reflux;
DOI:10.1021/jm101116s
- Guidance literature:
-
Multi-step reaction with 2 steps
1: lithium diisopropyl amide / tetrahydrofuran / -78 - -40 °C
2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane
With
N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); lithium diisopropyl amide;
In
tetrahydrofuran; tetrachloromethane;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: hydrogenchloride; sodium nitrate; sodium acetate; copper(II) sulfate; sodium sulfite / water
2: potassium hexamethylsilazane / toluene
3: periodic acid
5: lithium diisopropyl amide / tetrahydrofuran / -78 - -40 °C
6: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane
With
hydrogenchloride; sodium nitrate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium acetate; potassium hexamethylsilazane; copper(II) sulfate; periodic acid; sodium sulfite; lithium diisopropyl amide;
In
tetrahydrofuran; tetrachloromethane; water; toluene;
2: Wittig Reaction;
