4-(2-Chlorophenyl)-2-iodo-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine

Base Information

Chemical Name:4-(2-Chlorophenyl)-2-iodo-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
CAS No.:67860-41-7
Molecular Formula:C₁₅H₁₀ClIN₄S
Molecular Weight:440.695
Hs Code.:

Synonyms:4-(2-chlorophenyl)2-iodo-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine

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Chemical Property of 4-(2-Chlorophenyl)-2-iodo-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine

Chemical Property:

Melting Point:254-256 °C
Boiling Point:581.4±60.0 °C(Predicted)
PKA:2.03±0.40(Predicted)
Density:1.95±0.1 g/cm3(Predicted)

Purity/Quality:

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Technology Process of 4-(2-Chlorophenyl)-2-iodo-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine

There total 4 articles about 4-(2-Chlorophenyl)-2-iodo-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.5%

: 67860-46-2
5-(2-chlorophenyl)-2-hydrazino-7-iodo-3H-thieno<2,3-e><1,4>diazepine

: 78-39-7
Triethyl orthoacetate

: 67860-41-7
4-(2-chlorophenyl)2-iodo-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine

Guidance literature:: With toluene-4-sulfonic acid; In ethyl acetate; for 0.5h; Heating;
DOI:10.1021/jm00107a048

Reference yield:

: 67860-47-3
5-(2-chlorophenyl)-1,3-dihydro-7-iodo-2H-thieno<2,3-e><1,4>diazepin-2-thione

: 67860-41-7
4-(2-chlorophenyl)2-iodo-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine / tetrahydrofuran / 0.5 h / Ambient temperature

2: 74.5 percent / p-TSA / ethyl acetate / 0.5 h / Heating

With toluene-4-sulfonic acid; hydrazine; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/jm00107a048

Reference yield:

: 36811-58-2
5-(2-chlorophenyl)-1,3-dihydro-2H-thieno[2,3-e][4,1]diazepin-2-one

: 67860-41-7
4-(2-chlorophenyl)2-iodo-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine

Guidance literature:: Multi-step reaction with 4 steps

1: 59 percent / iodine monochloride, sodium acetate / acetic acid; methanol / 0.25 h / Ambient temperature

2: 89 percent / P₂S₅, NaHCO₃ / bis-(2-methoxy-ethyl) ether / 2 h / 70 - 80 °C

3: hydrazine / tetrahydrofuran / 0.5 h / Ambient temperature

4: 74.5 percent / p-TSA / ethyl acetate / 0.5 h / Heating

With tetraphosphorus decasulfide; sodium acetate; Iodine monochloride; sodium hydrogencarbonate; toluene-4-sulfonic acid; hydrazine; In tetrahydrofuran; methanol; diethylene glycol dimethyl ether; acetic acid; ethyl acetate;
DOI:10.1021/jm00107a048