5-(2-chlorophenyl)-1,3-dihydro-2H-thieno(2,3-e)(1,4)diazepin-2-one

Base Information

• Chemical Name: 5-(2-chlorophenyl)-1,3-dihydro-2H-thieno(2,3-e)(1,4)diazepin-2-one
• CAS No.: 36811-58-2
• Molecular Formula: C13H9 Cl N2 O S
• Molecular Weight: 276.74
• Hs Code.: 2934999090
• Mol file: 36811-58-2.mol

Synonyms:5-(2-chlorophenyl)-1,3-dihydro-2H-thieno(2,3-e)(1,4)diazepin-2-one

Chemical Property of 5-(2-chlorophenyl)-1,3-dihydro-2H-thieno(2,3-e)(1,4)diazepin-2-one

Chemical Property:

• Vapor Pressure: 2.69E-10mmHg at 25°C
• Boiling Point: 504.3°Cat760mmHg
• Flash Point: 258.8°C
• PSA: 69.70000
• Density: 1.48g/cm³
• LogP: 1.07180

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(2-chlorophenyl)-1,3-dihydro-2H-thieno(2,3-e)(1,4)diazepin-2-one

There total 5 articles about 5-(2-chlorophenyl)-1,3-dihydro-2H-thieno(2,3-e)(1,4)diazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

2-amino-N-[3-(2-chlorobenzoyl)thiophen-2-yl]acetamide (36811-56-0) → 2-Amino-3-(o-chlorobenzoyl)-thiophene (40017-58-1) + 5-(2-chlorophenyl)-1,3-dihydro-2H-thieno[2,3-e][4,1]diazepin-2-one (36811-58-2)

Guidance literature:

With acetic acid; for 0.25h; Further byproducts given; Heating;

DOI:10.1135/cccc19840621

Reference yield:

2-amino-N-[3-(2-chlorobenzoyl)thiophen-2-yl]acetamide (36811-56-0) → 5-(2-chlorophenyl)-1,3-dihydro-2H-thieno[2,3-e][4,1]diazepin-2-one (36811-58-2)

Guidance literature:

In dimethyl sulfoxide; at 100 ℃;

DOI:10.1246/bcsj.48.147

Reference yield:

2-Amino-3-(o-chlorobenzoyl)-thiophene (40017-58-1) → 5-(2-chlorophenyl)-1,3-dihydro-2H-thieno[2,3-e][4,1]diazepin-2-one (36811-58-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 43 percent / CHCl₃ / 1) after mixing slowly heated and refluxed 2 h, 2) standing overnight

2: 58 percent / hydrazine hydrate / methanol; CHCl₃; H₂O / 1) 45 deg C, 10 min, 2) 60 deg C, 1,5 h, 3) standing overnight

3: 13 percent / acetic acid / benzene; pyridine / 5.5 h / Heating

With hydrazine hydrate; acetic acid; In pyridine; methanol; chloroform; water; benzene;

DOI:10.1135/cccc19840621

upstream raw materials:

2-amino-N-[3-(2-chlorobenzoyl)thiophen-2-yl]acetamide

2-Amino-3-(o-chlorobenzoyl)-thiophene

3-(2-Chlorobenzoyl)-2-(phtalimidoacetamido)thiophene

Downstream raw materials:

5-(2-chloro-phenyl)-1-methyl-4-oxy-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one

4-(2-chloro-phenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine

5-(2-chloro-phenyl)-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one hydrazone

7-Bromo-5-(2-chlorophenyl)-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-thione

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