(S)-3-<(S)-1-carboxy-3-phenylpropyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid

Base Information

Chemical Name:(S)-3-<(S)-1-carboxy-3-phenylpropyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid
CAS No.:97871-10-8
Molecular Formula:C₂₁H₂₂N₂O₆
Molecular Weight:398.415
Hs Code.:

Synonyms:(S)-3-<(S)-1-carboxy-3-phenylpropyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid

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Chemical Property of (S)-3-<(S)-1-carboxy-3-phenylpropyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid

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Technology Process of (S)-3-<(S)-1-carboxy-3-phenylpropyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid

There total 5 articles about (S)-3-<(S)-1-carboxy-3-phenylpropyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 97871-08-4
3(S)-[1(S)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid hydrochloride

: 97871-10-8
(S)-3-<(S)-1-carboxy-3-phenylpropyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid

Guidance literature:: With sodium hydroxide; In ethanol; Ambient temperature;
DOI:10.1248/cpb.34.1128

Reference yield:

: 2021-28-5
ethyl dihydrocinnamate

: 97871-10-8
(S)-3-<(S)-1-carboxy-3-phenylpropyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1) NaOMe; 2) 15 percent H₂SO₄ / 1) MeOH, 60-70 deg C, 1.5 h; 2) reflux 15 h

2: ethanol; H₂SO₄ / 5 h / Heating

3: 40 percent / NaBH₃CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature

4: 85 percent / H₂, HCl / 10 percent Pd-C / ethanol / Ambient temperature

5: 72 percent / 1 N NaOH / ethanol / Ambient temperature

With hydrogenchloride; sodium hydroxide; 4 A molecular sieve; sulfuric acid; hydrogen; sodium methylate; sodium cyanoborohydride; palladium on activated charcoal; In ethanol; sulfuric acid; acetic acid;
DOI:10.1248/cpb.34.1128

Reference yield:

: 710-11-2
2-oxo-4-phenylbutyric acid

: 97871-10-8
(S)-3-<(S)-1-carboxy-3-phenylpropyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol; H₂SO₄ / 5 h / Heating

2: 40 percent / NaBH₃CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature

3: 85 percent / H₂, HCl / 10 percent Pd-C / ethanol / Ambient temperature

4: 72 percent / 1 N NaOH / ethanol / Ambient temperature

With hydrogenchloride; sodium hydroxide; 4 A molecular sieve; hydrogen; sodium cyanoborohydride; palladium on activated charcoal; In ethanol; sulfuric acid; acetic acid;
DOI:10.1248/cpb.34.1128