1-(1-benzylpiperidin-4-yl)-2-methyl-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine

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Chemical Name:1-(1-benzylpiperidin-4-yl)-2-methyl-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine
CAS No.:1315494-73-5
Molecular Formula:C₂₇H₂₇N₅O₂S
Molecular Weight:485.61
Hs Code.:

Synonyms:1-(1-benzylpiperidin-4-yl)-2-methyl-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine

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Chemical Property of 1-(1-benzylpiperidin-4-yl)-2-methyl-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine

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Technology Process of 1-(1-benzylpiperidin-4-yl)-2-methyl-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine

There total 4 articles about 1-(1-benzylpiperidin-4-yl)-2-methyl-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1315496-38-8
N₄-(1-benzylpiperidin-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo-[2,3-b]pyridine-4,5-diamine

: 122-51-0
orthoformic acid triethyl ester

: 1315494-73-5
1-(1-benzylpiperidin-4-yl)-2-methyl-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 20h; Inert atmosphere; Reflux;
DOI:10.1021/jm300628c

Reference yield:

: 1315496-35-5
N-[1-(phenylmethyl)-piperidin-4-yl]-5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-amine

: 1315494-73-5
1-(1-benzylpiperidin-4-yl)-2-methyl-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: iron; ammonium chloride / methanol; water / 4 h / Inert atmosphere; Reflux

2: toluene-4-sulfonic acid / toluene / 20 h / Inert atmosphere; Reflux

With iron; ammonium chloride; toluene-4-sulfonic acid; In methanol; water; toluene;
DOI:10.1021/jm300628c

Reference yield:

: 50541-93-0
4-amino-1-benzylpiperidine

: 1315494-73-5
1-(1-benzylpiperidin-4-yl)-2-methyl-6-(phenylsulfonyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.2 h / 120 °C / Inert atmosphere; Microwave irradiation

2: iron; ammonium chloride / methanol; water / 4 h / Inert atmosphere; Reflux

3: toluene-4-sulfonic acid / toluene / 20 h / Inert atmosphere; Reflux

With iron; ammonium chloride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In methanol; water; isopropyl alcohol; toluene;
DOI:10.1021/jm300628c