{4-[3-chloro-2-(2-methyl-2H-tetrazol-5-yl)-indol-1-yl]-benzyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{4-[3-chloro-2-(2-methyl-2H-tetrazol-5-yl)-indol-1-yl]-benzyl}-carbamic acid tert-butyl ester
CAS No.:1374451-87-2
Molecular Formula:C₂₂H₂₃ClN₆O₂
Molecular Weight:438.917
Hs Code.:

Synonyms:{4-[3-chloro-2-(2-methyl-2H-tetrazol-5-yl)-indol-1-yl]-benzyl}-carbamic acid tert-butyl ester

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Chemical Property of {4-[3-chloro-2-(2-methyl-2H-tetrazol-5-yl)-indol-1-yl]-benzyl}-carbamic acid tert-butyl ester

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Technology Process of {4-[3-chloro-2-(2-methyl-2H-tetrazol-5-yl)-indol-1-yl]-benzyl}-carbamic acid tert-butyl ester

There total 5 articles about {4-[3-chloro-2-(2-methyl-2H-tetrazol-5-yl)-indol-1-yl]-benzyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 489446-42-6
4-((tert-butoxycarbonylamino)methyl)phenylboronic acid

: 1374451-86-1
3-chloro-2-(2-methyl-2H-tetrazol-5-yl)-1H-indole

: 1374451-87-2
{4-[3-chloro-2-(2-methyl-2H-tetrazol-5-yl)-indol-1-yl]-benzyl}-carbamic acid tert-butyl ester

Guidance literature:: With copper diacetate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 72h; Molecular sieve;

Reference yield:

: 28737-32-8
3-chloro-1H-indole-2-carboxylic acid

: 1374451-87-2
{4-[3-chloro-2-(2-methyl-2H-tetrazol-5-yl)-indol-1-yl]-benzyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide; thionyl chloride / 3 h / Reflux

1.2: 2 h / Cooling with ice

2.1: trichlorophosphate / chloroform / 3 h / Reflux

3.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 3.5 h / Reflux

3.2: 16 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; copper diacetate / N,N-dimethyl-formamide / 72 h / 20 °C / Molecular sieve

With thionyl chloride; sodium azide; copper diacetate; ammonium chloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trichlorophosphate; In chloroform; N,N-dimethyl-formamide;

Reference yield:

Indole-2-carboxylic acid: 1477-50-5,1228050-17-6
Indole-2-carboxylic acid

: 1374451-87-2
{4-[3-chloro-2-(2-methyl-2H-tetrazol-5-yl)-indol-1-yl]-benzyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-chloro-succinimide / acetonitrile / 5 h / Reflux

2.1: N,N-dimethyl-formamide; thionyl chloride / 3 h / Reflux

2.2: 2 h / Cooling with ice

3.1: trichlorophosphate / chloroform / 3 h / Reflux

4.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 3.5 h / Reflux

4.2: 16 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; copper diacetate / N,N-dimethyl-formamide / 72 h / 20 °C / Molecular sieve

With N-chloro-succinimide; thionyl chloride; sodium azide; copper diacetate; ammonium chloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trichlorophosphate; In chloroform; N,N-dimethyl-formamide; acetonitrile;