1-(2,2,2-trifluoro-acetylamino)-cyclopropanecarboxylic acid 4-[3-chloro-2-(2-methyl-2H-tetrazol-5-yl)-indol-1-yl]-benzylamide

Base Information

Chemical Name:1-(2,2,2-trifluoro-acetylamino)-cyclopropanecarboxylic acid 4-[3-chloro-2-(2-methyl-2H-tetrazol-5-yl)-indol-1-yl]-benzylamide
CAS No.:1374453-31-2
Molecular Formula:C₂₃H₁₉ClF₃N₇O₂
Molecular Weight:517.898
Hs Code.:

Synonyms:1-(2,2,2-trifluoro-acetylamino)-cyclopropanecarboxylic acid 4-[3-chloro-2-(2-methyl-2H-tetrazol-5-yl)-indol-1-yl]-benzylamide

Suppliers and Price of 1-(2,2,2-trifluoro-acetylamino)-cyclopropanecarboxylic acid 4-[3-chloro-2-(2-methyl-2H-tetrazol-5-yl)-indol-1-yl]-benzylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(2,2,2-trifluoro-acetylamino)-cyclopropanecarboxylic acid 4-[3-chloro-2-(2-methyl-2H-tetrazol-5-yl)-indol-1-yl]-benzylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(2,2,2-trifluoro-acetylamino)-cyclopropanecarboxylic acid 4-[3-chloro-2-(2-methyl-2H-tetrazol-5-yl)-indol-1-yl]-benzylamide

There total 8 articles about 1-(2,2,2-trifluoro-acetylamino)-cyclopropanecarboxylic acid 4-[3-chloro-2-(2-methyl-2H-tetrazol-5-yl)-indol-1-yl]-benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.7%

: 1-amino-cyclopropanecarboxylic acid 4-[3-chloro-2-(2-methyl-2H-tetrazol-5-yl)-indol-1-yl]-benzylamide hydrochloride

: 407-25-0
trifluoroacetic anhydride

: 1374453-31-2
1-(2,2,2-trifluoro-acetylamino)-cyclopropanecarboxylic acid 4-[3-chloro-2-(2-methyl-2H-tetrazol-5-yl)-indol-1-yl]-benzylamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

Indole-2-carboxylic acid: 1477-50-5,1228050-17-6
Indole-2-carboxylic acid

: 1374453-31-2
1-(2,2,2-trifluoro-acetylamino)-cyclopropanecarboxylic acid 4-[3-chloro-2-(2-methyl-2H-tetrazol-5-yl)-indol-1-yl]-benzylamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-chloro-succinimide / acetonitrile / 5 h / Reflux

2.1: N,N-dimethyl-formamide; thionyl chloride / 3 h / Reflux

2.2: 2 h / Cooling with ice

3.1: trichlorophosphate / chloroform / 3 h / Reflux

4.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 3.5 h / Reflux

4.2: 16 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; copper diacetate / N,N-dimethyl-formamide / 72 h / 20 °C / Molecular sieve

6.1: hydrogenchloride / ethyl acetate / 16 h / 20 °C

7.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 24 h / 20 °C

8.1: hydrogenchloride / ethyl acetate / 6 h / 20 °C

9.1: triethylamine / dichloromethane / 3 h / 20 °C

With hydrogenchloride; N-chloro-succinimide; thionyl chloride; sodium azide; copper diacetate; ammonium chloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trichlorophosphate; In dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

3-chloro-1H-indole-2-carbonitrile: 74960-46-6
3-chloro-1H-indole-2-carbonitrile

: 1374453-31-2
1-(2,2,2-trifluoro-acetylamino)-cyclopropanecarboxylic acid 4-[3-chloro-2-(2-methyl-2H-tetrazol-5-yl)-indol-1-yl]-benzylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 3.5 h / Reflux

1.2: 16 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; copper diacetate / N,N-dimethyl-formamide / 72 h / 20 °C / Molecular sieve

3.1: hydrogenchloride / ethyl acetate / 16 h / 20 °C

4.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 24 h / 20 °C

5.1: hydrogenchloride / ethyl acetate / 6 h / 20 °C

6.1: triethylamine / dichloromethane / 3 h / 20 °C

With hydrogenchloride; sodium azide; copper diacetate; ammonium chloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;