3-benzyl-6-[4-(4-methyl-piperazine-1-sulfonyl)-2-propoxy-benzoylamino]-3H-benzoimidazole-5-carboxylic acid amide

Base Information

Chemical Name:3-benzyl-6-[4-(4-methyl-piperazine-1-sulfonyl)-2-propoxy-benzoylamino]-3H-benzoimidazole-5-carboxylic acid amide
CAS No.:269731-39-7
Molecular Formula:C₃₀H₃₄N₆O₅S
Molecular Weight:590.703
Hs Code.:

3-benzyl-6-[4-(4-methyl-piperazine-1-sulfonyl)-2-propoxy-benzoylamino]-3<i>H</i>-benzoimidazole-5-carboxylic acid amide

Synonyms:3-benzyl-6-[4-(4-methyl-piperazine-1-sulfonyl)-2-propoxy-benzoylamino]-3H-benzoimidazole-5-carboxylic acid amide

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Chemical Property of 3-benzyl-6-[4-(4-methyl-piperazine-1-sulfonyl)-2-propoxy-benzoylamino]-3H-benzoimidazole-5-carboxylic acid amide

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Technology Process of 3-benzyl-6-[4-(4-methyl-piperazine-1-sulfonyl)-2-propoxy-benzoylamino]-3H-benzoimidazole-5-carboxylic acid amide

There total 12 articles about 3-benzyl-6-[4-(4-methyl-piperazine-1-sulfonyl)-2-propoxy-benzoylamino]-3H-benzoimidazole-5-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 136833-36-8
5-chloro-2,4-dinitrobenzoic acid

: 269731-39-7
3-benzyl-6-[4-(4-methyl-piperazine-1-sulfonyl)-2-propoxy-benzoylamino]-3H-benzoimidazole-5-carboxylic acid amide

Guidance literature:: Multi-step reaction with 6 steps

1: SOCl₂ / dimethylformamide / 4 h / Heating

2: conc. aq. NH₄OH / 0.5 h / 0 °C

3: 95 percent / Et₃N / tetrahydrofuran / Heating

4: H₂ / PtO / methanol / 5 h

5: 20 °C

6: pyridine / dimethylformamide / 0.5 h / 75 °C

With pyridine; ammonium hydroxide; thionyl chloride; hydrogen; triethylamine; platinum(II) oxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 1: Chlorination / 2: Substitution / 3: Substitution / 4: Catalytic hydrogenation / 5: Cyclization / 6: Substitution;
DOI:10.1021/jm000081+

Reference yield:

: 50425-06-4
5-chloro-2,4-dinitrobenzoyl chloride

: 269731-39-7
3-benzyl-6-[4-(4-methyl-piperazine-1-sulfonyl)-2-propoxy-benzoylamino]-3H-benzoimidazole-5-carboxylic acid amide

Guidance literature:: Multi-step reaction with 5 steps

1: conc. aq. NH₄OH / 0.5 h / 0 °C

2: 95 percent / Et₃N / tetrahydrofuran / Heating

3: H₂ / PtO / methanol / 5 h

4: 20 °C

5: pyridine / dimethylformamide / 0.5 h / 75 °C

With pyridine; ammonium hydroxide; hydrogen; triethylamine; platinum(II) oxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 1: Substitution / 2: Substitution / 3: Catalytic hydrogenation / 4: Cyclization / 5: Substitution;
DOI:10.1021/jm000081+

Reference yield:

: 60532-50-5
5-chloro-2,4-dinitrobenzamide

: 269731-39-7
3-benzyl-6-[4-(4-methyl-piperazine-1-sulfonyl)-2-propoxy-benzoylamino]-3H-benzoimidazole-5-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / Et₃N / tetrahydrofuran / Heating

2: H₂ / PtO / methanol / 5 h

3: 20 °C

4: pyridine / dimethylformamide / 0.5 h / 75 °C

With pyridine; hydrogen; triethylamine; platinum(II) oxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 1: Substitution / 2: Catalytic hydrogenation / 3: Cyclization / 4: Substitution;
DOI:10.1021/jm000081+