2-[1-(N-benzoylamino)-2,2dimethylpropyl]-5-thiazolyl triflate

Base Information

• Chemical Name: 2-[1-(N-benzoylamino)-2,2dimethylpropyl]-5-thiazolyl triflate
• CAS No.: 1259400-22-0
• Molecular Formula: C₁₆H₁₇F₃N₂O₄S₂
• Molecular Weight: 422.449
• Mol file: 1259400-22-0.mol

Synonyms:2-[1-(N-benzoylamino)-2,2dimethylpropyl]-5-thiazolyl triflate

Chemical Property of 2-[1-(N-benzoylamino)-2,2dimethylpropyl]-5-thiazolyl triflate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[1-(N-benzoylamino)-2,2dimethylpropyl]-5-thiazolyl triflate

There total 1 articles about 2-[1-(N-benzoylamino)-2,2dimethylpropyl]-5-thiazolyl triflate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

trifluoromethylsulfonic anhydride (358-23-6) + 2-[1-(N-benzoylamino)-2,2-dimethylpropyl]-4H-5-thiazolone (1259400-09-3) → 2-[1-(N-benzoylamino)-2,2dimethylpropyl]-5-thiazolyl triflate (1259400-22-0)

Guidance literature:

In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1039/c0ob00453g

Reference yield: 95.0%

2-[1-(N-benzoylamino)-2,2dimethylpropyl]-5-thiazolyl triflate (1259400-22-0) + phenylacetylene (536-74-3) → 2-[1-(N-benzoylamino)-2,2-dimethylpropyl]-5-phenylethynylthiazole (1259400-28-6)

Guidance literature:

With 2,6-dimethylpyridine; copper(l) iodide; palladium diacetate; triphenylphosphine; In N,N-dimethyl-formamide; at 20 ℃; for 20h; Inert atmosphere;

DOI:10.1039/c0ob00453g

Reference yield: 73.0%

2-[1-(N-benzoylamino)-2,2dimethylpropyl]-5-thiazolyl triflate (1259400-22-0) + phenylboronic acid (98-80-6) → 2-[1-(N-benzoylamino)-2,2-dimethylpropyl]-5-phenyl thiazole (1259400-24-2)

Guidance literature:

With palladium diacetate; potassium carbonate; triphenylphosphine; In N,N-dimethyl-formamide; at 70 ℃; for 0.333333h; Inert atmosphere; Microwave irradiation;

DOI:10.1039/c0ob00453g

upstream raw materials:

trifluoromethylsulfonic anhydride

2-[1-(N-benzoylamino)-2,2-dimethylpropyl]-4H-5-thiazolone

Downstream raw materials:

2-[1-(N-benzoylamino)-2,2-dimethylpropyl]-5-phenylethynylthiazole

2-[1-(N-benzoylamino)-2,2-dimethylpropyl]-5-phenyl thiazole