2-[1-(N-benzoylamino)-2,2-dimethylpropyl]-4H-5-thiazolone

Base Information

• Chemical Name: 2-[1-(N-benzoylamino)-2,2-dimethylpropyl]-4H-5-thiazolone
• CAS No.: 1259400-09-3
• Molecular Formula: C₁₅H₁₈N₂O₂S
• Molecular Weight: 290.386
• Mol file: 1259400-09-3.mol

Synonyms:2-[1-(N-benzoylamino)-2,2-dimethylpropyl]-4H-5-thiazolone

Chemical Property of 2-[1-(N-benzoylamino)-2,2-dimethylpropyl]-4H-5-thiazolone

Chemical Property:

Purity/Quality:

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Technology Process of 2-[1-(N-benzoylamino)-2,2-dimethylpropyl]-4H-5-thiazolone

There total 1 articles about 2-[1-(N-benzoylamino)-2,2-dimethylpropyl]-4H-5-thiazolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

[2-(N-benzoylamino)-3,3-dimethyl-thiobutyryl]glycine (1259400-05-9) → 2-[1-(N-benzoylamino)-2,2-dimethylpropyl]-4H-5-thiazolone (1259400-09-3)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1039/c0ob00453g

Reference yield: 60.0%

trifluoromethylsulfonic anhydride (358-23-6) + 2-[1-(N-benzoylamino)-2,2-dimethylpropyl]-4H-5-thiazolone (1259400-09-3) → 2-[1-(N-benzoylamino)-2,2dimethylpropyl]-5-thiazolyl triflate (1259400-22-0)

Guidance literature:

In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1039/c0ob00453g

upstream raw materials:

[2-(N-benzoylamino)-3,3-dimethyl-thiobutyryl]glycine

Downstream raw materials:

2-[1-(N-benzoylamino)-2,2dimethylpropyl]-5-thiazolyl triflate