4-cyano-N-(2-((1-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)benzamide

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Chemical Name:4-cyano-N-(2-((1-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)benzamide
CAS No.:1610805-00-9
Molecular Formula:C₃₆H₃₄N₆O₄
Molecular Weight:614.704
Hs Code.:

Synonyms:4-cyano-N-(2-((1-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)benzamide

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Chemical Property of 4-cyano-N-(2-((1-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)benzamide

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Technology Process of 4-cyano-N-(2-((1-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)benzamide

There total 8 articles about 4-cyano-N-(2-((1-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.3%

: 1610805-35-0
C₁₇H₁₂N₂O₂

: 1610805-19-0
2-(2-(4-azidophenyl)ethyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 1610805-00-9
4-cyano-N-(2-((1-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)benzamide

Guidance literature:: With copper(II) sulfate; sodium L-ascorbate; In methanol; water; at 20 ℃;
DOI:10.1111/cbdd.12301

Reference yield:

: 88-75-5,78813-12-4
2-hydroxynitrobenzene

: 1610805-00-9
4-cyano-N-(2-((1-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 3 h / Reflux

2: ammonium chloride; iron / ethanol / 3.5 h / Reflux

3: triethylamine / dichloromethane / 24 h / 0 - 20 °C

4: copper(II) sulfate; sodium L-ascorbate / methanol; water / 20 °C

With iron; potassium carbonate; ammonium chloride; copper(II) sulfate; sodium L-ascorbate; triethylamine; In methanol; ethanol; dichloromethane; water; acetone;
DOI:10.1111/cbdd.12301

Reference yield:

: 2328-12-3
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline monohydrochloride

: 1610805-00-9
4-cyano-N-(2-((1-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetonitrile / 17 h / Reflux

2.1: hydrogen; palladium on activated charcoal / ethanol; dichloromethane / 24 h / 20 °C

3.1: acetic acid; sodium nitrite / 1.33 h / -5 - 5 °C

3.2: 1 h / 0 - 5 °C

4.1: copper(II) sulfate; sodium L-ascorbate / methanol; water / 20 °C

With palladium on activated charcoal; hydrogen; potassium carbonate; copper(II) sulfate; acetic acid; sodium L-ascorbate; sodium nitrite; In methanol; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1111/cbdd.12301