2-(2-(4-azidophenyl)ethyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:2-(2-(4-azidophenyl)ethyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
CAS No.:1610805-19-0
Molecular Formula:C₁₉H₂₂N₄O₂
Molecular Weight:338.409
Hs Code.:

Synonyms:2-(2-(4-azidophenyl)ethyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of 2-(2-(4-azidophenyl)ethyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of 2-(2-(4-azidophenyl)ethyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

There total 5 articles about 2-(2-(4-azidophenyl)ethyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 82925-02-8
4-<2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolyl)ethyl>benzenamine

: 1610805-19-0
2-(2-(4-azidophenyl)ethyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: 4-<2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolyl)ethyl>benzenamine; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 1h;

With sodium azide; In water; at 0 - 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2020.112958

Reference yield:

: 5339-26-4
(4-nitrophenyl)ethyl bromide

: 1610805-19-0
2-(2-(4-azidophenyl)ethyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 17 h / Reflux

2.1: hydrogen; palladium on activated charcoal / ethanol; dichloromethane / 24 h / 20 °C

3.1: acetic acid; sodium nitrite / 1.33 h / -5 - 5 °C

3.2: 1 h / 0 - 5 °C

With palladium on activated charcoal; hydrogen; potassium carbonate; acetic acid; sodium nitrite; In ethanol; dichloromethane; acetonitrile;
DOI:10.1111/cbdd.12301

Reference yield:

: 2328-12-3
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline monohydrochloride

: 1610805-19-0
2-(2-(4-azidophenyl)ethyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 17 h / Reflux

2.1: hydrogen; palladium on activated charcoal / ethanol; dichloromethane / 24 h / 20 °C

3.1: acetic acid; sodium nitrite / 1.33 h / -5 - 5 °C

3.2: 1 h / 0 - 5 °C

With palladium on activated charcoal; hydrogen; potassium carbonate; acetic acid; sodium nitrite; In ethanol; dichloromethane; acetonitrile;
DOI:10.1111/cbdd.12301