ethyl 4-(5-oxo-3-phenylbenzo[4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-4(5H)-yl)butanoate

Base Information

• Chemical Name: ethyl 4-(5-oxo-3-phenylbenzo[4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-4(5H)-yl)butanoate
• CAS No.: 1430822-05-1
• Molecular Formula: C₂₃H₂₀N₄O₃S
• Molecular Weight: 432.503
• Mol file: 1430822-05-1.mol

Synonyms:ethyl 4-(5-oxo-3-phenylbenzo[4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-4(5H)-yl)butanoate

Chemical Property of ethyl 4-(5-oxo-3-phenylbenzo[4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-4(5H)-yl)butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4-(5-oxo-3-phenylbenzo[4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-4(5H)-yl)butanoate

There total 4 articles about ethyl 4-(5-oxo-3-phenylbenzo[4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-4(5H)-yl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

Ethyl 4-bromobutyrate (2969-81-5) + 3-phenylbenzo[4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5(4H)-one (1430822-01-7) → ethyl 4-(5-oxo-3-phenylbenzo[4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-4(5H)-yl)butanoate (1430822-05-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 16h;

DOI:10.1016/j.ejmech.2013.01.019

Reference yield: 26.0%

Ethyl 4-bromobutyrate (2969-81-5) + 3-phenylbenzo[4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5(4H)-one (1430822-01-7) → ethyl 4-(5-oxo-3-phenylbenzo[4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-4(5H)-yl)butanoate (1430822-05-1) + ethyl 4-(10-oxo-3-phenylbenzo[4,5]thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidin-4(10H)-yl)butanoate (1448687-66-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 4h; Reflux;

DOI:10.1016/j.ejmech.2013.05.012

Reference yield:

ethyl 3-aminobenzothiophene-2-carboxylate (34761-09-6) → ethyl 4-(5-oxo-3-phenylbenzo[4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-4(5H)-yl)butanoate (1430822-05-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium nitrite; acetic acid / water / 0.5 h / -5 °C

1.2: 3 h / 20 °C

2.1: sodium ethanolate / ethanol / 0.25 h / 20 °C

2.2: 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C

With sodium ethanolate; potassium carbonate; acetic acid; sodium nitrite; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2013.01.019

upstream raw materials:

ethyl 3-aminobenzothiophene-2-carboxylate

ethyl 3-azido-benzo[b]thiophene-2-carboxylate

Ethyl 4-bromobutyrate

3-phenylbenzo[4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5(4H)-one

Downstream raw materials:

C₂₁H₁₆N₄O₃S

C₂₆H₂₃N₇O₂S