3-phenylbenzo[4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5(4H)-one

Base Information

• Chemical Name: 3-phenylbenzo[4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5(4H)-one
• CAS No.: 1430822-01-7
• Molecular Formula: C₁₇H₁₀N₄OS
• Molecular Weight: 318.359
• Mol file: 1430822-01-7.mol

Synonyms:3-phenylbenzo[4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5(4H)-one

Chemical Property of 3-phenylbenzo[4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5(4H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-phenylbenzo[4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5(4H)-one

There total 2 articles about 3-phenylbenzo[4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

ethyl 3-azido-benzo[b]thiophene-2-carboxylate (1430821-99-0) + phenylacetonitrile (140-29-4) → 3-phenylbenzo[4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5(4H)-one (1430822-01-7)

Guidance literature:

phenylacetonitrile; With sodium ethanolate; In ethanol; at 20 ℃; for 0.25h;

ethyl 3-azido-benzo[b]thiophene-2-carboxylate; In ethanol; at 20 ℃;

DOI:10.1016/j.ejmech.2013.01.019

Reference yield:

ethyl 3-aminobenzothiophene-2-carboxylate (34761-09-6) → 3-phenylbenzo[4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5(4H)-one (1430822-01-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium nitrite; acetic acid / water / 0.5 h / -5 °C

1.2: 3 h / 20 °C

2.1: sodium ethanolate / ethanol / 0.25 h / 20 °C

2.2: 20 °C

With sodium ethanolate; acetic acid; sodium nitrite; In ethanol; water;

DOI:10.1016/j.ejmech.2013.01.019

Reference yield: 40.0%

Ethyl 4-bromobutyrate (2969-81-5) + 3-phenylbenzo[4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5(4H)-one (1430822-01-7) → ethyl 4-(5-oxo-3-phenylbenzo[4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-4(5H)-yl)butanoate (1430822-05-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 16h;

DOI:10.1016/j.ejmech.2013.01.019

upstream raw materials:

ethyl 3-aminobenzothiophene-2-carboxylate

ethyl 3-azido-benzo[b]thiophene-2-carboxylate

phenylacetonitrile

Downstream raw materials:

C₂₁H₁₆N₄O₃S

C₂₆H₂₃N₇O₂S

ethyl 4-(5-oxo-3-phenylbenzo[4,5]thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-4(5H)-yl)butanoate

4-(10-oxo-3-phenylbenzo[4,5]thieno[3,2-d][1,2,3]triazolo[1,5-a]pyrimidin-4(10H)-yl)butanoic acid