3-[4-amino-5-(4-nitro-phenyl)-thieno[2,3-d]pyrimidin-6-yl]-N,N-dimethyl-propionamide

Base Information

Chemical Name:3-[4-amino-5-(4-nitro-phenyl)-thieno[2,3-d]pyrimidin-6-yl]-N,N-dimethyl-propionamide
CAS No.:866582-50-5
Molecular Formula:C₁₇H₁₇N₅O₃S
Molecular Weight:371.42
Hs Code.:

3-[4-amino-5-(4-nitro-phenyl)-thieno[2,3-<i>d</i>]pyrimidin-6-yl]-<i>N</i>,<i>N</i>-dimethyl-propionamide

Synonyms:3-[4-amino-5-(4-nitro-phenyl)-thieno[2,3-d]pyrimidin-6-yl]-N,N-dimethyl-propionamide

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Chemical Property of 3-[4-amino-5-(4-nitro-phenyl)-thieno[2,3-d]pyrimidin-6-yl]-N,N-dimethyl-propionamide

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Technology Process of 3-[4-amino-5-(4-nitro-phenyl)-thieno[2,3-d]pyrimidin-6-yl]-N,N-dimethyl-propionamide

There total 5 articles about 3-[4-amino-5-(4-nitro-phenyl)-thieno[2,3-d]pyrimidin-6-yl]-N,N-dimethyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 866582-02-7
3-(4-amino-5-phenylthieno[2,3-d]pyrimidin-6-yl)-N,N-dimethylpropanamide

: 866582-50-5
3-[4-amino-5-(4-nitro-phenyl)-thieno[2,3-d]pyrimidin-6-yl]-N,N-dimethyl-propionamide

Guidance literature:: With sulfuric acid; nitric acid; at 0 - 20 ℃; for 1.75h;
DOI:10.1021/jm050458h

Reference yield:

: 607713-80-4
6,6-dicyano-5-phenylhex-5-enoic acid

: 866582-50-5
3-[4-amino-5-(4-nitro-phenyl)-thieno[2,3-d]pyrimidin-6-yl]-N,N-dimethyl-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: HOBt; EDC; NMM / dimethylformamide / 20 °C

2: Et₂NH; sulfur / ethanol / 1.5 h / 70 °C

3: 17 h / 155 °C

4: HNO₃; H₂SO₄ / 1.75 h / 0 - 20 °C

With 4-methyl-morpholine; sulfuric acid; nitric acid; benzotriazol-1-ol; sulfur; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; diethylamine; In ethanol; N,N-dimethyl-formamide; 2: Gewald reaction;
DOI:10.1021/jm050458h

Reference yield:

: 607713-83-7
6,6-dicyano-N,N-dimethyl-5-phenyl-5-hexenamide

: 866582-50-5
3-[4-amino-5-(4-nitro-phenyl)-thieno[2,3-d]pyrimidin-6-yl]-N,N-dimethyl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: Et₂NH; sulfur / ethanol / 1.5 h / 70 °C

2: 17 h / 155 °C

3: HNO₃; H₂SO₄ / 1.75 h / 0 - 20 °C

With sulfuric acid; nitric acid; sulfur; diethylamine; In ethanol; 1: Gewald reaction;
DOI:10.1021/jm050458h