methyl 3-(5-((benzyl)-(2-iodophenyl)amino)-2-methyloxazol-4-yl)propanoate

Base Information

Chemical Name:methyl 3-(5-((benzyl)-(2-iodophenyl)amino)-2-methyloxazol-4-yl)propanoate
CAS No.:1298035-55-8
Molecular Formula:C₂₁H₂₁IN₂O₃
Molecular Weight:476.314
Hs Code.:

Synonyms:methyl 3-(5-((benzyl)-(2-iodophenyl)amino)-2-methyloxazol-4-yl)propanoate

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Chemical Property of methyl 3-(5-((benzyl)-(2-iodophenyl)amino)-2-methyloxazol-4-yl)propanoate

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Technology Process of methyl 3-(5-((benzyl)-(2-iodophenyl)amino)-2-methyloxazol-4-yl)propanoate

There total 6 articles about methyl 3-(5-((benzyl)-(2-iodophenyl)amino)-2-methyloxazol-4-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1298035-50-3
methyl 3-(5-(2-iodophenylamino)-2-methyloxazol-4-yl)propanoate

: 100-39-0
benzyl bromide

: 1298035-55-8
methyl 3-(5-((benzyl)-(2-iodophenyl)amino)-2-methyloxazol-4-yl)propanoate

Guidance literature:: methyl 3-(5-(2-iodophenylamino)-2-methyloxazol-4-yl)propanoate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.25h; Inert atmosphere;

benzyl bromide; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1055/s-0030-1259302

Reference yield:

: 1298035-68-3
methyl 4-(tert-butoxycarbonylamino)-5-(2-iodophenylamino)-5-oxopentanoate

: 1298035-55-8
methyl 3-(5-((benzyl)-(2-iodophenyl)amino)-2-methyloxazol-4-yl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: pyridine / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid; trifluoroacetic anhydride / dichloromethane / 36 h / 20 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere

4.2: 0 - 20 °C / Inert atmosphere

With pyridine; sodium hydride; trifluoroacetic acid; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1055/s-0030-1259302

Reference yield:

: C₁₂H₁₅IN₂O₃

: 1298035-55-8
methyl 3-(5-((benzyl)-(2-iodophenyl)amino)-2-methyloxazol-4-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid; trifluoroacetic anhydride / dichloromethane / 36 h / 20 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

With pyridine; sodium hydride; trifluoroacetic acid; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1055/s-0030-1259302