4-{4-n-butyl-1-(2-tolyl)-1H-1,2,3-triazol-5-yl}benzoic acid ethyl ester

Base Information

• Chemical Name: 4-{4-n-butyl-1-(2-tolyl)-1H-1,2,3-triazol-5-yl}benzoic acid ethyl ester
• CAS No.: 1111662-50-0
• Molecular Formula: C₂₂H₂₅N₃O₂
• Molecular Weight: 363.459
• Mol file: 1111662-50-0.mol

Synonyms:4-{4-n-butyl-1-(2-tolyl)-1H-1,2,3-triazol-5-yl}benzoic acid ethyl ester

Chemical Property of 4-{4-n-butyl-1-(2-tolyl)-1H-1,2,3-triazol-5-yl}benzoic acid ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 4-{4-n-butyl-1-(2-tolyl)-1H-1,2,3-triazol-5-yl}benzoic acid ethyl ester

There total 2 articles about 4-{4-n-butyl-1-(2-tolyl)-1H-1,2,3-triazol-5-yl}benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

Ethyl 4-bromobenzoate (5798-75-4) + 4-n-butyl-1-(2-tolyl)-1H-1,2,3-triazole (1027335-43-8) → 4-{4-n-butyl-1-(2-tolyl)-1H-1,2,3-triazol-5-yl}benzoic acid ethyl ester (1111662-50-0)

Guidance literature:

With mesitylenecarboxylic acid; 5 mol% Pd/C; potassium trifluoroacetate; at 150 ℃; for 16h; Inert atmosphere; Green chemistry;

DOI:10.1039/c6cc03468c

Reference yield: 68.0%

4-n-butyl-1-(2-tolyl)-1H-1,2,3-triazole (1027335-43-8) + ethyl 4-chlorobenzoate (7335-27-5) → 4-{4-n-butyl-1-(2-tolyl)-1H-1,2,3-triazol-5-yl}benzoic acid ethyl ester (1111662-50-0)

Guidance literature:

With palladium diacetate; potassium carbonate; tricyclohexylphosphine; In toluene; at 120 ℃; for 22h; regioselective reaction; Inert atmosphere;

DOI:10.1002/adsc.200800016

upstream raw materials:

4-n-butyl-1-(2-tolyl)-1H-1,2,3-triazole

ethyl 4-chlorobenzoate

Ethyl 4-bromobenzoate