3'-(5-bromo-thiophen-2-yl)-1'-phenyl-5-p-tolyl-3,4-dihydro-2H,1'H-[3,4']bipyrazolyl

Base Information

• Chemical Name: 3'-(5-bromo-thiophen-2-yl)-1'-phenyl-5-p-tolyl-3,4-dihydro-2H,1'H-[3,4']bipyrazolyl
• CAS No.: 701935-74-2
• Molecular Formula: C₂₃H₁₉BrN₄S
• Molecular Weight: 463.401
• Mol file: 701935-74-2.mol

Synonyms:3'-(5-bromo-thiophen-2-yl)-1'-phenyl-5-p-tolyl-3,4-dihydro-2H,1'H-[3,4']bipyrazolyl

Chemical Property of 3'-(5-bromo-thiophen-2-yl)-1'-phenyl-5-p-tolyl-3,4-dihydro-2H,1'H-[3,4']bipyrazolyl

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-(5-bromo-thiophen-2-yl)-1'-phenyl-5-p-tolyl-3,4-dihydro-2H,1'H-[3,4']bipyrazolyl

There total 2 articles about 3'-(5-bromo-thiophen-2-yl)-1'-phenyl-5-p-tolyl-3,4-dihydro-2H,1'H-[3,4']bipyrazolyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-[3-(5-bromo-thiophen-2-yl)-1-phenyl-1H-pyrazol-4-yl]-1-p-tolyl-propenone → 3'-(5-bromo-thiophen-2-yl)-1'-phenyl-5-p-tolyl-3,4-dihydro-2H,1'H-[3,4']bipyrazolyl (701935-74-2)

Guidance literature:

With hydrazine hydrate; In ethanol; for 0.5h; Heating;

DOI:10.1016/j.bmc.2004.01.037

Reference yield:

3-(5-bromo-2-thienyl)-1-phenyl-1H-pyrazole-4-carboxaldehyde (274900-91-3) → 3'-(5-bromo-thiophen-2-yl)-1'-phenyl-5-p-tolyl-3,4-dihydro-2H,1'H-[3,4']bipyrazolyl (701935-74-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / KOH / ethanol / 4 h / 20 °C

2: 87 percent / NH₂NH₂*H₂O / ethanol / 0.5 h / Heating

With potassium hydroxide; hydrazine hydrate; In ethanol;

DOI:10.1016/j.bmc.2004.01.037

Reference yield: 93.0%

acetyl chloride (75-36-5) + 3'-(5-bromo-thiophen-2-yl)-1'-phenyl-5-p-tolyl-3,4-dihydro-2H,1'H-[3,4']bipyrazolyl (701935-74-2) → 1-[3'-(5-bromo-thiophen-2-yl)-1'-phenyl-5-p-tolyl-3,4-dihydro-1'H-[3,4']bipyrazolyl-2-yl]-ethanone

Guidance literature:

With pyridine; for 0.333333h; Heating;

DOI:10.1016/j.bmc.2004.01.037

upstream raw materials:

3-(5-bromo-2-thienyl)-1-phenyl-1H-pyrazole-4-carboxaldehyde