Methanesulfonic acid (R)-1-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-pent-4-enyl ester

Base Information

Chemical Name:Methanesulfonic acid (R)-1-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-pent-4-enyl ester
CAS No.:423763-82-0
Molecular Formula:C₂₀H₃₄O₄SSi
Molecular Weight:398.639
Hs Code.:

Synonyms:Methanesulfonic acid (R)-1-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-pent-4-enyl ester

Suppliers and Price of Methanesulfonic acid (R)-1-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-pent-4-enyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methanesulfonic acid (R)-1-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-pent-4-enyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of Methanesulfonic acid (R)-1-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-pent-4-enyl ester

There total 8 articles about Methanesulfonic acid (R)-1-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-pent-4-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 124-63-0
methanesulfonyl chloride

: 423763-81-9
(1R,3R)-1-(tert-Butyl-dimethyl-silanyloxy)-1-phenyl-hept-6-en-3-ol

: 423763-82-0
Methanesulfonic acid (R)-1-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-pent-4-enyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.166667h;
DOI:10.1016/S0040-4039(01)02105-0

Reference yield:

: 6249-80-5
1-phenylbut-3-en-1-one

: 423763-82-0
Methanesulfonic acid (R)-1-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-pent-4-enyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 84 percent / (+)-Ipc₂BCl / tetrahydrofuran / 12 h / -35 °C

2: 90 percent / n-BuLi / diethyl ether; tetrahydrofuran / 2.5 h / -78 - 20 °C

3: 85 percent / IBr / toluene; CH₂Cl₂ / 1 h / -85 °C

4: 96 percent / K₂CO₃ / methanol / 2 h / 20 °C

5: 96 percent / Et₃N; DMAP / dimethylformamide / 3 h / 20 °C

6: 91 percent / CuI / diethyl ether / 0.5 h / -40 °C

7: 88 percent / Et₃N / CH₂Cl₂ / 0.17 h / 0 °C

With dmap; copper(l) iodide; n-butyllithium; (+)-β-chlorodiisopinocampheylborane; iodine(I) bromide; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(01)02105-0

Reference yield:

: 85551-57-1,936-58-3
(R)-1-Phenylbut-3-en-1-ol

: 423763-82-0
Methanesulfonic acid (R)-1-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-pent-4-enyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / n-BuLi / diethyl ether; tetrahydrofuran / 2.5 h / -78 - 20 °C

2: 85 percent / IBr / toluene; CH₂Cl₂ / 1 h / -85 °C

3: 96 percent / K₂CO₃ / methanol / 2 h / 20 °C

4: 96 percent / Et₃N; DMAP / dimethylformamide / 3 h / 20 °C

5: 91 percent / CuI / diethyl ether / 0.5 h / -40 °C

6: 88 percent / Et₃N / CH₂Cl₂ / 0.17 h / 0 °C

With dmap; copper(l) iodide; n-butyllithium; iodine(I) bromide; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(01)02105-0