ethyl 2-(2,4-dichlorophenyl)-1-(4-(3-fluoropropoxy)phenyl)-5-methyl-1H-imidazole-4-carboxylate

Base Information

Chemical Name:ethyl 2-(2,4-dichlorophenyl)-1-(4-(3-fluoropropoxy)phenyl)-5-methyl-1H-imidazole-4-carboxylate
CAS No.:930283-29-7
Molecular Formula:C₂₂H₂₁Cl₂FN₂O₃
Molecular Weight:451.325
Hs Code.:

Synonyms:ethyl 2-(2,4-dichlorophenyl)-1-(4-(3-fluoropropoxy)phenyl)-5-methyl-1H-imidazole-4-carboxylate

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Chemical Property of ethyl 2-(2,4-dichlorophenyl)-1-(4-(3-fluoropropoxy)phenyl)-5-methyl-1H-imidazole-4-carboxylate

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Technology Process of ethyl 2-(2,4-dichlorophenyl)-1-(4-(3-fluoropropoxy)phenyl)-5-methyl-1H-imidazole-4-carboxylate

There total 6 articles about ethyl 2-(2,4-dichlorophenyl)-1-(4-(3-fluoropropoxy)phenyl)-5-methyl-1H-imidazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 930283-17-3
ethyl 2-(2,4-dichlorophenyl)-1-(4-hydroxyphenyl)-5-methyl-1H-imidazole-4-carboxylate

: 462-43-1
3-fluoropropane-1-ol

: 930283-29-7
ethyl 2-(2,4-dichlorophenyl)-1-(4-(3-fluoropropoxy)phenyl)-5-methyl-1H-imidazole-4-carboxylate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 20 ℃;

Reference yield:

: 6574-98-7
2,4-dichlorobenzylnitrile

: 930283-29-7
ethyl 2-(2,4-dichlorophenyl)-1-(4-(3-fluoropropoxy)phenyl)-5-methyl-1H-imidazole-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethylmagnesium bromide / tetrahydrofuran / 0.33 h / Inert atmosphere

1.2: 20 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / tetrahydrofuran / 0.17 h

2.2: 67 h / 20 °C

3.1: acetic acid; hydrogen bromide / 20 °C / Darkness

4.1: hydrogenchloride; magnesium sulfate / 1,4-dioxane / 2.5 h / Reflux

5.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 15 h / 20 °C

With hydrogenchloride; ethylmagnesium bromide; hydrogen bromide; magnesium sulfate; potassium carbonate; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; toluene;
DOI:10.1021/acs.jmedchem.7b00861

Reference yield:

: 866598-55-2
N-(4-(benzyloxy)phenyl)-2,4-dichlorobenzamidine

: 930283-29-7
ethyl 2-(2,4-dichlorophenyl)-1-(4-(3-fluoropropoxy)phenyl)-5-methyl-1H-imidazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrahydrofuran / 0.17 h

1.2: 67 h / 20 °C

2.1: acetic acid; hydrogen bromide / 20 °C / Darkness

3.1: hydrogenchloride; magnesium sulfate / 1,4-dioxane / 2.5 h / Reflux

4.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 15 h / 20 °C

With hydrogenchloride; hydrogen bromide; magnesium sulfate; potassium carbonate; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; toluene;
DOI:10.1021/acs.jmedchem.7b00861