462-43-1Relevant articles and documents
Preparation method of 3-fluoro-1-propanol
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Paragraph 0007; 0028-0056, (2022/03/18)
The present invention discloses a method for preparing 3- fluoro-1-propanol, the method is as follows: under the protection of nitrogen or argon, spray-dried potassium fluoride, 3-chloro-1-propanol as raw material, diethylene glycol as a solvent, polyethylene glycol --400 (PEG--400) as a phase transfer catalyst (PTC), in the pressure-resistant upper head connected to the filler distillation column in the reaction kettle while stirring reaction while distillation, while collecting the boiling range at the top of the distillation column between 120 ° C - --140 ° C initial fractions The collected primary fraction is re-distilled once, and the fraction with a boiling range of 127.5 °C to 128.5 °C is collected, that is, the product 3-fluoro-1-propanol. The purity of the product is detected by gas chromatograph; the structure of the product is characterized by nuclear magnetic resonance hydrogen spectroscopy and nuclear magnetic resonance carbon spectroscopy. The present invention takes the method of distillation while reacting to prepare 3-fluoro-1-propanol, the required equipment is simple, the investment is small, the by-products in the reaction process are few and easy to remove, the solvent diethylene glycol can be recycled and recycled many times, and it is easy to achieve industrial production.
Towards the development of new subtype-specific muscarinic receptor radiopharmaceuticals - Radiosynthesis and ex vivo biodistribution of [ 18F]3-(4-(2-(2-(2-fluoroethoxy)ethoxy)ethylthio)-1,2, 5-thiadiazol-3-yl)-1-methyl-1,2,5,6-tetrahydropyrid
Van Oosten, Erik M.,Wilson, Alan A.,Mamo, David C.,Pollock, Bruce G.,Mulsant, Benoit H.,Houle, Sylvain,Vasdev, Neil
experimental part, p. 1222 - 1232 (2011/02/24)
Muscarinic receptors have been implicated in neurological disorders including Alzheimer's disease, Parkinson's disease, and schizophrenia. Nineteen derivatives of thiadiazolyltetrahydropyridine (TZTP), a core that has previously shown high affinities towa
INTERMEDIATES FOR FLUORINATED DIHYDROTETRABENAZINE ETHER IMAGING AGENTS AND PROBES
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Page/Page column 21-22, (2009/05/28)
The present invention provides novel fluorophilic compounds having structure VI wherein R1 is a C2-C20 aliphatic, a C3-C20 cycloaliphatic, or a C3-C20 aromatic radical comprising at least one functional group susceptible to reaction with nucleophilic fluoride ion or an electrophilic fluorinating agent; R2 is a C1-C10 aliphatic radical, or a C3-C10 cycloaliphatic radical; R3 is hydrogen or a C1-C10 aliphatic radical; and R4 is hydrogen or a C1-C10 aliphatic radical. The fluorophilic compounds are provided in both racemic and enantiomerically enriched forms and are useful as intermediates in the preparation of novel PET imaging agents and probes useful in the discovery and performance assessment of PET imaging agents. The fluorophilic compounds are particularly useful in the preparation of PET imaging agents and probes having a high affinity for VMAT-2, a biomarker implicated in human diabetes and other illnesses such as Parkinson's disease.