rac-5-(3-aminophenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Base Information

Chemical Name:rac-5-(3-aminophenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine
CAS No.:1352419-10-3
Molecular Formula:C₁₁H₁₅N₃O
Molecular Weight:205.26
Hs Code.:

Synonyms:rac-5-(3-aminophenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of rac-5-(3-aminophenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

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Technology Process of rac-5-(3-aminophenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

There total 7 articles about rac-5-(3-aminophenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1352419-09-0
rac-5-(3-bromophenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine trifluoroacetate

: 1352419-10-3
rac-5-(3-aminophenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Guidance literature:: rac-5-(3-bromophenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine trifluoroacetate; With Benzophenone imine; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In toluene; at 20 - 80 ℃; for 7h; Sealed tube; Inert atmosphere;

With hydrogenchloride; water; In tetrahydrofuran; toluene; at 20 ℃;

With sodium carbonate; In water;

Reference yield:

: 2142-63-4
1-(3-Bromophenyl)ethanone

: 1352419-10-3
rac-5-(3-aminophenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonium chloride / ammonia; methanol / 96 h / 20 °C

2.1: hydrogenchloride / 96 h / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / -78 °C

4.2: 1.5 h / -15 - 0 °C

5.1: tetraphosphorus decasulfide / tetrahydrofuran / 1 h / 20 - 50 °C

6.1: ammonia / water / 4 h / 60 °C / Sealed tube

7.1: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; Benzophenone imine / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 7 h / 20 - 80 °C / Sealed tube; Inert atmosphere

7.2: 20 °C

With hydrogenchloride; Benzophenone imine; lithium aluminium tetrahydride; tetraphosphorus decasulfide; ammonia; ammonium chloride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; methanol; ammonia; water; toluene;

Reference yield:

: 1262858-68-3
rac-5-(3-bromophenyl)-5-methylmorpholine-3-thione

: 1352419-10-3
rac-5-(3-aminophenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonia / water / 4 h / 60 °C / Sealed tube

2.1: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; Benzophenone imine / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 7 h / 20 - 80 °C / Sealed tube; Inert atmosphere

2.2: 20 °C

With Benzophenone imine; ammonia; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In water; toluene;