rac-5-(3-bromophenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine trifluoroacetate

Base Information

Chemical Name:rac-5-(3-bromophenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine trifluoroacetate
CAS No.:1352419-09-0
Molecular Formula:C₂HF₃O₂*C₁₁H₁₃BrN₂O
Molecular Weight:383.165
Hs Code.:

Synonyms:rac-5-(3-bromophenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine trifluoroacetate

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Chemical Property of rac-5-(3-bromophenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine trifluoroacetate

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Technology Process of rac-5-(3-bromophenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine trifluoroacetate

There total 6 articles about rac-5-(3-bromophenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1262858-68-3
rac-5-(3-bromophenyl)-5-methylmorpholine-3-thione

: 76-05-1
trifluoroacetic acid

: 1352419-09-0
rac-5-(3-bromophenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine trifluoroacetate

Guidance literature:: rac-5-(3-bromophenyl)-5-methylmorpholine-3-thione; With ammonia; In water; at 60 ℃; for 4h; Sealed tube;

trifluoroacetic acid; In dichloromethane;

Reference yield:

: 2142-63-4
1-(3-Bromophenyl)ethanone

: 1352419-09-0
rac-5-(3-bromophenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium chloride / ammonia; methanol / 96 h / 20 °C

2.1: hydrogenchloride / 96 h / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / -78 °C

4.2: 1.5 h / -15 - 0 °C

5.1: tetraphosphorus decasulfide / tetrahydrofuran / 1 h / 20 - 50 °C

6.1: ammonia / water / 4 h / 60 °C / Sealed tube

With hydrogenchloride; lithium aluminium tetrahydride; tetraphosphorus decasulfide; ammonia; ammonium chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ammonia; water;

Reference yield:

: 953741-63-4
rac-2-amino-2-(3-bromo-phenyl)-propionitrile

: 1352419-09-0
rac-5-(3-bromophenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / 96 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / -78 °C

3.2: 1.5 h / -15 - 0 °C

4.1: tetraphosphorus decasulfide / tetrahydrofuran / 1 h / 20 - 50 °C

5.1: ammonia / water / 4 h / 60 °C / Sealed tube

With hydrogenchloride; lithium aluminium tetrahydride; tetraphosphorus decasulfide; ammonia; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water;