1-Chloromethyl-2,6-dimethyl-3-[3-[4-(methylcarbamoyl)-cinnamoylamino]phenyl]benzene

Base Information

Chemical Name:1-Chloromethyl-2,6-dimethyl-3-[3-[4-(methylcarbamoyl)-cinnamoylamino]phenyl]benzene
CAS No.:189269-09-8
Molecular Formula:C₂₆H₂₅ClN₂O₂
Molecular Weight:432.95
Hs Code.:

Synonyms:1-Chloromethyl-2,6-dimethyl-3-[3-[4-(methylcarbamoyl)-cinnamoylamino]phenyl]benzene

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Chemical Property of 1-Chloromethyl-2,6-dimethyl-3-[3-[4-(methylcarbamoyl)-cinnamoylamino]phenyl]benzene

Chemical Property:

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Technology Process of 1-Chloromethyl-2,6-dimethyl-3-[3-[4-(methylcarbamoyl)-cinnamoylamino]phenyl]benzene

There total 6 articles about 1-Chloromethyl-2,6-dimethyl-3-[3-[4-(methylcarbamoyl)-cinnamoylamino]phenyl]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.9%

: 189269-08-7
1-Hydroxymethyl-2,6-dimethyl-3-[3-[4-(methylcarbamoyl)-cinnamoylamino]phenyl]benzene

: 189269-09-8
1-Chloromethyl-2,6-dimethyl-3-[3-[4-(methylcarbamoyl)-cinnamoylamino]phenyl]benzene

Guidance literature:: With methanesulfonyl chloride; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 4.5h;
DOI:10.1021/jm980330i

Reference yield:

: 1-tert-butyldiphenylsilyloxymethyl-2,6-dimethyl-3-bromobenzene

: 189269-09-8
1-Chloromethyl-2,6-dimethyl-3-[3-[4-(methylcarbamoyl)-cinnamoylamino]phenyl]benzene

Guidance literature:: Multi-step reaction with 4 steps

1: 34.1 percent / tetrakis(triphenylphosphine)palladium⁽⁰⁾, 2 M aq. Na₂CO₃ / methanol; toluene / 5 h / 80 °C

2: HOBt, WSCD*HCl / dimethylformamide / 2.5 h / 0 - 20 °C

3: tetrabutylammonium fluoride / tetrahydrofuran / 1 h / Ambient temperature

4: 93.9 percent / methanesulfonyl chloride, Et₃N / dimethylformamide / 4.5 h / 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; WSCD*HCl; tetrabutyl ammonium fluoride; sodium carbonate; benzotriazol-1-ol; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm980330i

Reference yield:

: 189269-03-2
3-(3-aminophenyl)-1-tert-butyldiphenylsilyloxymethyl-2,6-dimethylbenzene

: 189269-09-8
1-Chloromethyl-2,6-dimethyl-3-[3-[4-(methylcarbamoyl)-cinnamoylamino]phenyl]benzene

Guidance literature:: Multi-step reaction with 3 steps

1: HOBt, WSCD*HCl / dimethylformamide / 2.5 h / 0 - 20 °C

2: tetrabutylammonium fluoride / tetrahydrofuran / 1 h / Ambient temperature

3: 93.9 percent / methanesulfonyl chloride, Et₃N / dimethylformamide / 4.5 h / 0 - 20 °C

With WSCD*HCl; tetrabutyl ammonium fluoride; benzotriazol-1-ol; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm980330i