(3aR,4R,7R,7aR)-7-hydroxy-2,2-dimethyl-5-(4'-methoxybenzenesulfonyl)hexahydro[1,3]dioxolo[4,5-c]-4-carboxylic acid methyl ester

Base Information

Chemical Name:(3aR,4R,7R,7aR)-7-hydroxy-2,2-dimethyl-5-(4'-methoxybenzenesulfonyl)hexahydro[1,3]dioxolo[4,5-c]-4-carboxylic acid methyl ester
CAS No.:683210-67-5
Molecular Formula:C₁₇H₂₃NO₈S
Molecular Weight:401.438
Hs Code.:

Synonyms:(3aR,4R,7R,7aR)-7-hydroxy-2,2-dimethyl-5-(4'-methoxybenzenesulfonyl)hexahydro[1,3]dioxolo[4,5-c]-4-carboxylic acid methyl ester

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Chemical Property of (3aR,4R,7R,7aR)-7-hydroxy-2,2-dimethyl-5-(4'-methoxybenzenesulfonyl)hexahydro[1,3]dioxolo[4,5-c]-4-carboxylic acid methyl ester

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Technology Process of (3aR,4R,7R,7aR)-7-hydroxy-2,2-dimethyl-5-(4'-methoxybenzenesulfonyl)hexahydro[1,3]dioxolo[4,5-c]-4-carboxylic acid methyl ester

There total 5 articles about (3aR,4R,7R,7aR)-7-hydroxy-2,2-dimethyl-5-(4'-methoxybenzenesulfonyl)hexahydro[1,3]dioxolo[4,5-c]-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 683210-64-2
(1S,2R,4'R,5'S)-[5'-(1-hydroxy-2-methanesulfonyloxyethyl)-2',2'-dimethyl[1,3]dioxolan-4'-yl]-(4-methoxybenzenesulfonylamino)acetic acid methyl ester

: 683210-67-5
(3aR,4R,7R,7aR)-7-hydroxy-2,2-dimethyl-5-(4'-methoxybenzenesulfonyl)hexahydro[1,3]dioxolo[4,5-c]-4-carboxylic acid methyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 45 ℃; for 1.16667h;
DOI:10.1021/jm0304313

Reference yield:

: (2R,4'S,4R,5'R)-azide-(2',2',2,2-tetramethyl-[4',4]bis[[1,3]dioxolanyl]-5'-yl)-acetic acid methyl ester

: 683210-67-5
(3aR,4R,7R,7aR)-7-hydroxy-2,2-dimethyl-5-(4'-methoxybenzenesulfonyl)hexahydro[1,3]dioxolo[4,5-c]-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd/C / ethyl acetate / 4 h / 40 °C / 3040 Torr

2: 4-DMAP / dimethylformamide / 20 °C

3: 74 percent / cerium chloride heptahydrate; oxalic acid / acetonitrile / 1.17 h / 20 °C

4: 73 percent / triethylamine / CH₂Cl₂ / 1 h / -40 °C

5: 68 percent / potassium carbonate / dimethylformamide / 1.17 h / 45 °C

With dmap; cerium(III) chloride; hydrogen; oxalic acid; potassium carbonate; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm0304313

Reference yield:

: 98-68-0
4-methoxy-phenyl-sulphonyl chloride

: 683210-67-5
(3aR,4R,7R,7aR)-7-hydroxy-2,2-dimethyl-5-(4'-methoxybenzenesulfonyl)hexahydro[1,3]dioxolo[4,5-c]-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 4-DMAP / dimethylformamide / 20 °C

2: 74 percent / cerium chloride heptahydrate; oxalic acid / acetonitrile / 1.17 h / 20 °C

3: 73 percent / triethylamine / CH₂Cl₂ / 1 h / -40 °C

4: 68 percent / potassium carbonate / dimethylformamide / 1.17 h / 45 °C

With dmap; cerium(III) chloride; oxalic acid; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm0304313