N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-6-[2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-3-pyridinesulfonamide

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Chemical Name:N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-6-[2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-3-pyridinesulfonamide
CAS No.:1089669-57-7
Molecular Formula:C₂₄H₂₄N₄O₆S₃
Molecular Weight:560.676
Hs Code.:

Synonyms:N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-6-[2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-3-pyridinesulfonamide

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Chemical Property of N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-6-[2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-3-pyridinesulfonamide

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Technology Process of N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-6-[2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-3-pyridinesulfonamide

There total 7 articles about N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-6-[2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-3-pyridinesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1014613-31-0
benzenesulfonyl-2-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine

: 1089669-43-1
6-chloro-N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-pyridinesulfonamide

: 1089669-57-7
N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-6-[2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-3-pyridinesulfonamide

Guidance literature:: With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 150 ℃; for 1h; Product distribution / selectivity; Microwave irradiation;

Reference yield:

: 889939-25-7
1-(benzenesulfonyl)-4-bromo-1H-pyrrolo[2,3-b]pyridine

: 1089669-57-7
N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-6-[2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-3-pyridinesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.5 h / -35 °C

1.2: 2 h / 20 °C

2.1: potassium acetate / palladium diacetate / dichloromethane / 0.08 h / 20 °C

2.2: 20 - 65 °C

3.1: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water / 0.5 h / 120 °C / Microwave irradiation

With potassium acetate; sodium hydrogencarbonate; lithium diisopropyl amide; palladium diacetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; n-heptane; dichloromethane; ethylbenzene; water;

Reference yield:

: 6684-39-5
2-chloropyridine-5-sulfonyl chloride

: 1089669-57-7
N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-6-[2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-3-pyridinesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 19 h / 20 °C

2: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water / 0.5 h / 120 °C / Microwave irradiation

With sodium hydrogencarbonate; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In dichloromethane; water;