Technology Process of 1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL-1-(PHENYLSULFONYL)-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-
There total 5 articles about 1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL-1-(PHENYLSULFONYL)-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-(benzenesulfonyl)-4-bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine;
With
potassium acetate;
palladium diacetate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.0833333h;
bis(pinacol)diborane;
In
N,N-dimethyl-formamide;
at 20 - 65 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere
1.2: 2 h / 20 °C
2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C
2.2: 0 - 20 °C
3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate / 1,4-dioxane
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; sodium hydride; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; mineral oil;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere
1.2: 2 h / 20 °C
2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C
2.2: 0 - 20 °C
3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate / 1,4-dioxane
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; sodium hydride; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; mineral oil;
