1-[2-(4-chlorophenyl)-2-oxoethyl]-2(1H)-pyridinone

Base Information

• Chemical Name: 1-[2-(4-chlorophenyl)-2-oxoethyl]-2(1H)-pyridinone
• CAS No.: 108664-55-7
• Molecular Formula: C₁₃H₁₀ClNO₂
• Molecular Weight: 247.681
• Hs Code.: 2933399990
• DSSTox Substance ID: DTXSID901328733
• ChEMBL ID: CHEMBL1706368
• Mol file: 108664-55-7.mol

Synonyms:108664-55-7;1-[2-(4-chlorophenyl)-2-oxoethyl]-2(1H)-pyridinone;1-[2-(4-chlorophenyl)-2-oxoethyl]-1,2-dihydropyridin-2-one;1-[2-(4-chlorophenyl)-2-oxoethyl]pyridin-2-one;1-(2-(4-chlorophenyl)-2-oxoethyl)pyridin-2(1H)-one;1-[2-(4-chlorophenyl)-2-oxoethyl]pyridin-2(1H)-one;Oprea1_688483;MLS000420291;F0017-0440;SCHEMBL9685245;CHEMBL1706368;DTXSID901328733;HMS1609N09;HMS2691E04;MFCD00139074;STL281714;AKOS003621084;CCG-105506;SMR000322754;CS-0325297;EU-0003619;8B-068

Chemical Property of 1-[2-(4-chlorophenyl)-2-oxoethyl]-2(1H)-pyridinone

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 247.0400063
• Heavy Atom Count: 17
• Complexity: 368

Purity/Quality:

99% ^*data from raw suppliers

1-[2-(4-Chlorophenyl)-2-oxoethyl]-1,2-dihydropyridin-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=O)N(C=C1)CC(=O)C2=CC=C(C=C2)Cl

Technology Process of 1-[2-(4-chlorophenyl)-2-oxoethyl]-2(1H)-pyridinone

There total 1 articles about 1-[2-(4-chlorophenyl)-2-oxoethyl]-2(1H)-pyridinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Pyridone (142-08-5,1199357-22-6) + 4-chlorobenzoylmethyl bromide (536-38-9) → 1-[2-(4-Chloro-phenyl)-2-oxo-ethyl]-1H-pyridin-2-one (108664-55-7)

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; for 0.5h; Ambient temperature;

DOI:10.1021/jm00391a037

Reference yield: 73.0%

4-fluorobenzaldehyde (459-57-4) + 1-[2-(4-Chloro-phenyl)-2-oxo-ethyl]-1H-pyridin-2-one (108664-55-7) → 4'-chloro-4-fluoro-α-(2-oxo-1,2-dihydropyridin-1-yl)-chalcone (104941-02-8)

Guidance literature:

With piperidine; acetic acid; In toluene; for 2h; Heating;

DOI:10.1021/jm00391a037

Reference yield: 47.0%

propionaldehyde (123-38-6) + 1-[2-(4-Chloro-phenyl)-2-oxo-ethyl]-1H-pyridin-2-one (108664-55-7) → 1-[(Z)-1-(4-Chloro-benzoyl)-but-1-enyl]-1H-pyridin-2-one (104941-03-9)

Guidance literature:

With piperidine; acetic acid; In toluene; for 5h; Heating;

DOI:10.1021/jm00391a037

upstream raw materials:

2-Pyridone

4-chlorobenzoylmethyl bromide

Downstream raw materials:

1-[1-(4-Chloro-benzoyl)-vinyl]-1H-pyridin-2-one

4'-chloro-4-fluoro-α-(2-oxo-1,2-dihydropyridin-1-yl)-chalcone

1-[(Z)-1-(4-Chloro-benzoyl)-but-1-enyl]-1H-pyridin-2-one

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