methyl N^α-{1-[(2,4-diaminopteridin-6-yl)methyl]indolin-5-ylcarbonyl}-N^δ-(3-ethoxycarbonylphenyl)-L-glutaminate

Base Information

• Chemical Name: methyl N^α-{1-[(2,4-diaminopteridin-6-yl)methyl]indolin-5-ylcarbonyl}-N^δ-(3-ethoxycarbonylphenyl)-L-glutaminate
• CAS No.: 142166-28-7
• Molecular Formula: C₃₁H₃₃N₉O₆
• Molecular Weight: 627.66

Synonyms:methyl N^α-{1-[(2,4-diaminopteridin-6-yl)methyl]indolin-5-ylcarbonyl}-N^δ-(3-ethoxycarbonylphenyl)-L-glutaminate

Chemical Property of methyl N^α-{1-[(2,4-diaminopteridin-6-yl)methyl]indolin-5-ylcarbonyl}-N^δ-(3-ethoxycarbonylphenyl)-L-glutaminate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl N^α-{1-[(2,4-diaminopteridin-6-yl)methyl]indolin-5-ylcarbonyl}-N^δ-(3-ethoxycarbonylphenyl)-L-glutaminate

There total 8 articles about methyl N^α-{1-[(2,4-diaminopteridin-6-yl)methyl]indolin-5-ylcarbonyl}-N^δ-(3-ethoxycarbonylphenyl)-L-glutaminate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-aminobenzoic acid ethyl ester (582-33-2) → methyl Nα-{1-[(2,4-diaminopteridin-6-yl)methyl]indolin-5-ylcarbonyl}-Nδ-(3-ethoxycarbonylphenyl)-L-glutaminate (142166-28-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 69 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) / CH₂Cl₂ / Ambient temperature

2: 88 percent / TFA / 0.5 h / Ambient temperature

3: aq. K₂CO₃ / CH₂Cl₂ / 10 h / Ambient temperature

4: H₂ / 5percent Pd/C / methanol / Ambient temperature

5: N,N-dimethyl-acetamide / 6 h / 55 °C

With hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl acetamide;

DOI:10.1248/cpb.45.1146

Reference yield:

N-tert-butoxycarbonylglutamic acid methyl ester (72086-72-7) → methyl Nα-{1-[(2,4-diaminopteridin-6-yl)methyl]indolin-5-ylcarbonyl}-Nδ-(3-ethoxycarbonylphenyl)-L-glutaminate (142166-28-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 69 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) / CH₂Cl₂ / Ambient temperature

2: 88 percent / TFA / 0.5 h / Ambient temperature

3: aq. K₂CO₃ / CH₂Cl₂ / 10 h / Ambient temperature

4: H₂ / 5percent Pd/C / methanol / Ambient temperature

5: N,N-dimethyl-acetamide / 6 h / 55 °C

With hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl acetamide;

DOI:10.1248/cpb.45.1146

Reference yield:

5-Chlorocarbonyl-2,3-dihydro-indole-1-carboxylic acid benzyl ester (156578-52-8) → methyl Nα-{1-[(2,4-diaminopteridin-6-yl)methyl]indolin-5-ylcarbonyl}-Nδ-(3-ethoxycarbonylphenyl)-L-glutaminate (142166-28-7)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. K₂CO₃ / CH₂Cl₂ / 10 h / Ambient temperature

2: H₂ / 5percent Pd/C / methanol / Ambient temperature

3: N,N-dimethyl-acetamide / 6 h / 55 °C

With hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl acetamide;

DOI:10.1248/cpb.45.1146

upstream raw materials:

6-bromomethyl-2,4-diaminopteridine hydrobromide

3-{(S)-4-[(2,3-Dihydro-1H-indole-5-carbonyl)-amino]-4-methoxycarbonyl-butyrylamino}-benzoic acid ethyl ester

3-aminobenzoic acid ethyl ester

N-tert-butoxycarbonylglutamic acid methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 142166-28-7 methyl N^α-{1-[(2,4-diaminopteridin-6-yl)methyl]indolin-5-ylcarbonyl}-N^δ-(3-ethoxycarbonylphenyl)-L-glutaminate

Send

Send

Metric Ton KG G Pound L ML

Send

Send