156578-52-8

Basic information

• Product Name: 5-Chlorocarbonyl-2,3-dihydro-indole-1-carboxylic acid benzyl ester
• CAS NO: 156578-52-8
• Molecular Weight: 315.756
• Mol File: 156578-52-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-Chlorocarbonyl-2,3-dihydro-indole-1-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chlorocarbonyl-2,3-dihydro-indole-1-carboxylic acid benzyl ester(156578-52-8)
• EPA Substance Registry System: 5-Chlorocarbonyl-2,3-dihydro-indole-1-carboxylic acid benzyl ester(156578-52-8)

Safety Data

• Hazardous Substances Data: 156578-52-8(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 15861-30-0 2,3-dihydro-1H-indole-5-formic acid 
• 142165-63-7 1-carbobenzoxy-5-carboxyindoline 

Downstream Products

• 142165-67-1 (S)-2-[(1-Benzyloxycarbonyl-2,3-dihydro-1H-indole-5-carbonyl)-amino]-hexanedioic acid dimethyl ester 
• 142166-28-7 methyl N^α-{1-[(2,4-diaminopteridin-6-yl)methyl]indolin-5-ylcarbonyl}-N^δ-(3-ethoxycarbonylphenyl)-L-glutaminate 
• 142166-24-3 methyl N^α-{1-[(2,4-diaminopteridin-6-yl)methyl]indolin-5-ylcarbonyl}-N^δ-phenyl-L-glutaminate 
• 142165-91-1 3-{(S)-4-[(2,3-Dihydro-1H-indole-5-carbonyl)-amino]-4-methoxycarbonyl-butyrylamino}-benzoic acid ethyl ester 
• 142165-84-2 (S)-2-[(2,3-Dihydro-1H-indole-5-carbonyl)-amino]-4-phenylcarbamoyl-butyric acid methyl ester 
• 194206-09-2 methyl N^α-[(1-benzyloxycarbonylindolin-5-yl)carbonyl]-N^δ-[2-(ethoxycarbonyl)cyclopropylcarbonyl]-L-ornithinate 
• 194206-08-1 methyl N^α-[(1-benzyloxycarbonylindolin-5-yl)carbonyl]-N^δ-succinyl-L-ornithinate 
• 142165-83-1 methyl N^α-[(1-benzyloxycarbonylindolin-5-yl)carbonyl]-N^δ-phenyl-L-glutaminate 
• 142165-94-4 methyl N^α-[(1-benzyloxycarbonylindolin-5-yl)carbonyl]-N^δ-dimethyl-L-glutaminate 
• 142165-90-0 methyl N^α-[(1-benzyloxycarbonylindolin-5-yl)carbonyl]-N^δ-(3-ethoxycarbonylphenyl)-L-glutaminate 

Relevant articles and documents

Antirheumatic agents. III. Novel methotrexate derivatives bearing an indoline ring and a modified ornithine or glutamie acid

The synthesis, biological profile and structure-activity relationship of various methotrexate (MTX) derivatives bearing an indoline ring are described. In particular, Nδ-(3-carboxyphenyl)-Nα-[1-[(2,4-diaminopteridin- 6-yl)methyl]indoline-5-ylcarbonyl]-L-glutamine (3d), compared to MTX; exhibited an enhanced anti-proliferative effect on human peripheral blood mononuclear cells obtained from healthy volunteers.