3-diphenylphosphinoisoquinolone

Base Information

• Chemical Name: 3-diphenylphosphinoisoquinolone
• CAS No.: 851542-17-1
• Molecular Formula: C₂₁H₁₆NOP
• Molecular Weight: 329.338
• Mol file: 851542-17-1.mol

Synonyms:3-diphenylphosphinoisoquinolone

Chemical Property of 3-diphenylphosphinoisoquinolone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-diphenylphosphinoisoquinolone

There total 4 articles about 3-diphenylphosphinoisoquinolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.8%

3-chloroisoquinolin-1(2H)-one (7742-74-7) + triphenylphosphine (603-35-0) → 3-diphenylphosphinoisoquinolone (851542-17-1)

Guidance literature:

triphenylphosphine; With ammonia; sodium; at -78 ℃; for 2h;

3-chloroisoquinolin-1(2H)-one; In tetrahydrofuran; at 60 ℃; for 20h;

Reference yield:

3-bromo-1-tert-butoxyisoquinoline (851542-16-0) + chloro-diphenylphosphine (1079-66-9,74391-44-9) → 3-diphenylphosphinoisoquinolone (851542-17-1)

Guidance literature:

3-bromo-1-tert-butoxyisoquinoline; With n-butyllithium; In tetrahydrofuran; at -100 ℃;

chloro-diphenylphosphine; at -100 - 20 ℃;

DOI:10.1002/anie.200462499

Reference yield:

1,3-dibromoisoquinoline (53987-60-3) → 3-diphenylphosphinoisoquinolone (851542-17-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene / 80 °C

2.1: nBuLi / tetrahydrofuran / -100 °C

2.2: -100 - 20 °C

With n-butyllithium; In tetrahydrofuran; toluene;

DOI:10.1002/anie.200462499

upstream raw materials:

3-bromo-1-tert-butoxyisoquinoline

chloro-diphenylphosphine

1,3-dibromoisoquinoline

3-chloroisoquinolin-1(2H)-one

Downstream raw materials:

[Ru(η5-C5H5)(acetonitrile)(3-diphenylphosphinoisoquinolone)2]PF6

[Ru(η5-C5H5)(acetonitrile)(6-diphenylphosphino-N-pivaloyl-2-aminopyridine)(3-diphenylphosphinoisoquinolone)]PF6

C₄₇H₄₁Cl₂N₃O₂P₂Pt

C₅₁H₄₁Cl₂N₃O₄P₂Pt

Refernces

• 1、 Breit, Bernhard,Seiche, Wolfgang. "Self-assembly of bidentate ligands for combinatorial homogeneous catalysis based on an A-T base-pair model". . p. 1640 - 1643. Retrieved 2007/10/03.