7742-74-7

Usage

Uses

Used in Pharmaceutical Industry:
3-CHLORO-2H-ISOQUINOLIN-1-ONE is used as an intermediate in the synthesis of pharmaceuticals for its contribution to the development of new drugs.
Used in Agrochemical Industry:
3-CHLORO-2H-ISOQUINOLIN-1-ONE is used as an intermediate in the synthesis of agrochemicals for its contribution to the development of new agricultural products.
Used in Organic Synthesis:
3-CHLORO-2H-ISOQUINOLIN-1-ONE is used as a reagent in organic synthesis and chemical research for its role in creating various bioactive molecules.
Used in Medicinal Chemistry and Drug Discovery:
3-CHLORO-2H-ISOQUINOLIN-1-ONE may have potential applications in the field of medicinal chemistry and drug discovery due to its unique chemical structure and biological activity.

Upstream product

• 7742-73-6 1,3-dichloroisoquinoline 
• 24649-22-7 1-Chloro-3-methoxyisoquinoline 
• 1076-37-5 3-chloro-1-fluoro-isoquinoline 
• 6627-91-4 2-cyanomethylbenzoic acid 
• 15028-10-1 indan-1,2-dione-2-oxime 
• 1241384-74-6 1-tert-butoxy-3-chloroisoquinoline 

Downstream Products

• 5597-04-6 2-cyanomethylbenzoic acid methyl ester 
• 491-30-5 1-isoquinolone 
• 59048-50-9 3-methoxy-1,2-dihydro-1-isoquinolinone 
• 59048-51-0 3-ethoxy-2H-isoquinolin-1-one 
• 19821-21-7 (2-carbethoxyphenyl)acetonitrile 
• 82083-85-0 3-chloro-2-phenethyl-1-isoquinolone 
• 1239024-36-2 8-phenylbenzo[a]phenanthridin-5-one 
• 1239024-50-0 3-(2-phenylallyl)isoquinolin-1-one 
• 1239024-33-9 8-methylbenzo[a]phenanthridin-5-one 
• 1330074-83-3 C₁₉H₁₅Cl₂NO 
• 1330074-70-8 C₂₁H₁₈ClNO 
• 1330074-84-4 C₂₁H₂₀ClNO 
• 1330074-87-7 C₂₀H₁₇Cl₂NO 
• 1330074-81-1 C₂₀H₁₈ClNO 

Relevant academic research and scientific papers

One-step hydroxylation of aryl and heteroaryl fluorides using mechanochemistry

Simple use of KOH allows the direct F to OH exchange of aromatic and heteroaromatic substrates under mechanochemical conditions. The reaction is performed in the absence of solvent with potassium hydroxide as OH source. As a result, this approach is both more atom economical and environmentally friendly than previously described methods for this transformation.

Synthesis of Acyl Fluorides via DAST-Mediated Fluorinative C-C Bond Cleavage of Activated Ketones

A new protocol for preparation of acyl fluorides was developed by recognizing activated ketones as starting materials. The method provides a different scope compared with previously reported methods that employ carboxylic acids as substrates. A working hypothesis of pull-and-push-driven fluorinative C-C bond cleavage was successfully demonstrated by the simple addition of diethylaminosulfur trifluoride (DAST) derivatives to α-oximinoketones. The designed reaction system led to a highly efficient and chemoselective reaction. The wide availability of the ketones allowed for a range of synthetically useful aryloyl and aliphatic acyl fluorides including those containing chiral skeletons. The method is mild, fast, scalable, and potentially one-pot operative.

One-pot synthesis of benzo[f]quinolin-3-ones and benzo[a]phenanthridein-5- ones by the photoanuulation of 6-chloropyridin-2-ones and 3-chloroisoquinolin-1- ones to phenylacetylene

The one-pot synthesis of benzo[f]quinolin-3-ones and benzo[a] phenanthridein-5-ones was achieved by the inter- and intramolecular photoannulation of 6-chloropyridin-2-ones and 3-chloroisoquinolin-1-ones with phenylacetylene or tethered phenylacetylene. The reactions were proceeded by photoaddition of 6-chloropyridin-2-ones and 3-chloroisoquinolin-1-ones to phenylacetylene to give the chlorine-substituted stilbenoids, and then 6π electrocyclization of the stilbenoids and oxidation aromatization to afford the polycyclic products.

One-pot synthesis of benzo[a]phenanthridin-5-ones by photoinduced cycloaddition of 3-chloroisoquinolin-1-ones with styrenes

One-pot synthesis of benzo[a]phenanthridin-5-ones and benzo[k] phenanthridin-6-ones in fairly good yields was achieved by the photocycloaddition reactions of 3-chloroisoquinolin-1-ones and 3-chloroquinolin-2-ones with styrenes. The reactions were proceeded via photoinduced dechlorinative coupling of 3-chloroisoquinolin-1-ones and 3-chloroquinolin-2-ones with styrenes and subsequent photocyclization, oxidative aromatization.

Hydroformylation

The present invention relates to a process for hydroformylating in the presence of a catalyst comprising at least one complex of a metal of transition group VIII with mono-phosphorus compounds which are capable of dimerizing via noncovalent bonds as ligands, to such catalysts and to their use.