2-tert-butoxycarbonylamino-N-([1-(1-adamantylmethyl)-5-[2-(morpholin-4-yl)ethyl]-2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl])-3-phenylpropionamide

Base Information

Chemical Name:2-tert-butoxycarbonylamino-N-([1-(1-adamantylmethyl)-5-[2-(morpholin-4-yl)ethyl]-2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl])-3-phenylpropionamide
CAS No.:1322056-30-3
Molecular Formula:C₄₀H₅₃N₅O₆
Molecular Weight:699.891
Hs Code.:

2-tert-butoxycarbonylamino-N-([1-(1-adamantylmethyl)-5-[2-(morpholin-4-yl)ethyl]-2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl])-3-phenylpropionamide

Synonyms:2-tert-butoxycarbonylamino-N-([1-(1-adamantylmethyl)-5-[2-(morpholin-4-yl)ethyl]-2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl])-3-phenylpropionamide

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Chemical Property of 2-tert-butoxycarbonylamino-N-([1-(1-adamantylmethyl)-5-[2-(morpholin-4-yl)ethyl]-2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl])-3-phenylpropionamide

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Technology Process of 2-tert-butoxycarbonylamino-N-([1-(1-adamantylmethyl)-5-[2-(morpholin-4-yl)ethyl]-2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl])-3-phenylpropionamide

There total 8 articles about 2-tert-butoxycarbonylamino-N-([1-(1-adamantylmethyl)-5-[2-(morpholin-4-yl)ethyl]-2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl])-3-phenylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 18942-49-9
Boc-D-Phe-OH

: 1-(1-adamantyl)methyl-3-amino-2,4-dioxo-5-[2-(morpholin-4-yl)ethyl]-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

: 1322056-30-3
2-tert-butoxycarbonylamino-N-([1-(1-adamantylmethyl)-5-[2-(morpholin-4-yl)ethyl]-2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl])-3-phenylpropionamide

Guidance literature:: Boc-D-Phe-OH; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In ethyl acetate; at 23 ℃; for 1h;

1-(1-adamantyl)methyl-3-amino-2,4-dioxo-5-[2-(morpholin-4-yl)ethyl]-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine; In ethyl acetate; at 23 ℃; for 3h;
DOI:10.1016/j.bmc.2011.05.057

Reference yield:

: 163617-93-4
N-(1-adamantyl)methyl-N'-[2-(morpholin-4-yl)ethyl]-1,2-phenylenediamine

: 1322056-30-3
2-tert-butoxycarbonylamino-N-([1-(1-adamantylmethyl)-5-[2-(morpholin-4-yl)ethyl]-2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl])-3-phenylpropionamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethyl acetate / 2 h / Reflux

2.1: acetic acid; zinc / 0.25 h / 23 °C

2.2: pH 10

3.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / ethyl acetate / 1 h / 23 °C

3.2: 3 h / 23 °C

With benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; zinc; In ethyl acetate;
DOI:10.1016/j.bmc.2011.05.057

Reference yield:

: 163617-94-5
1-(1-adamantyl)methyl-2,4-dioxo-5-[2-(morpholin-4-yl)ethyl]-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

: 1322056-30-3
2-tert-butoxycarbonylamino-N-([1-(1-adamantylmethyl)-5-[2-(morpholin-4-yl)ethyl]-2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl])-3-phenylpropionamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid; zinc / 0.25 h / 23 °C

1.2: pH 10

2.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / ethyl acetate / 1 h / 23 °C

2.2: 3 h / 23 °C

With benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; zinc; In ethyl acetate;
DOI:10.1016/j.bmc.2011.05.057