2-butyl-4-chloro-1-[4-(2-carbomethoxyphenoxy)benzyl]-5-hydroxymethylimidazole

Base Information

• Chemical Name: 2-butyl-4-chloro-1-[4-(2-carbomethoxyphenoxy)benzyl]-5-hydroxymethylimidazole
• CAS No.: 114772-89-3
• Molecular Formula: C₂₃H₂₅ClN₂O₄
• Molecular Weight: 428.915
• Mol file: 114772-89-3.mol

Synonyms:2-butyl-4-chloro-1-[4-(2-carbomethoxyphenoxy)benzyl]-5-hydroxymethylimidazole

Chemical Property of 2-butyl-4-chloro-1-[4-(2-carbomethoxyphenoxy)benzyl]-5-hydroxymethylimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-butyl-4-chloro-1-[4-(2-carbomethoxyphenoxy)benzyl]-5-hydroxymethylimidazole

There total 6 articles about 2-butyl-4-chloro-1-[4-(2-carbomethoxyphenoxy)benzyl]-5-hydroxymethylimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-butyl-4(5)-chloro-5(4)-hydroxymethyl imidazole + methyl 2-[4-(bromomethyl)phenoxy]benzoate (30087-38-8) → 2-butyl-4-chloro-1-[4-(2-carbomethoxyphenoxy)benzyl]-5-hydroxymethylimidazole (114772-89-3)

Guidance literature:

With sodium methylate; In N-methyl-acetamide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

methyl 2-(4-methylphenoxy)benzoate (21905-72-6) → 2-butyl-4-chloro-1-[4-(2-carbomethoxyphenoxy)benzyl]-5-hydroxymethylimidazole (114772-89-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N-bromosuccinimide, azobisisobutyronitrile / CCl₄ / 3 h / Heating

2: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) 40 deg C, 4 h

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium methylate; In tetrachloromethane;

DOI:10.1021/jm00167a008

Reference yield:

p-cresol (106-44-5) → 2-butyl-4-chloro-1-[4-(2-carbomethoxyphenoxy)benzyl]-5-hydroxymethylimidazole (114772-89-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 50 percent / potassium carbonate, copper(I) iodide / dimethylformamide / 16 h / Heating

2: 88 percent / conc. H₂SO₄ / 14 h / Heating

3: N-bromosuccinimide, azobisisobutyronitrile / CCl₄ / 3 h / Heating

4: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) 40 deg C, 4 h

With N-Bromosuccinimide; copper(l) iodide; 2,2'-azobis(isobutyronitrile); sulfuric acid; sodium methylate; potassium carbonate; In tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00167a008

upstream raw materials:

methyl 2-[4-(bromomethyl)phenoxy]benzoate

2-n-butyl-4-chloro-5-hydroxymethylimidazole

p-cresol

2-(4-methylphenoxy)-benzoic acid

Downstream raw materials:

2-butyl-1-<4-(2-carboxyphenoxy)benzyl>-4-chloro-5-(hydroxymethyl)imidazole