21905-72-6

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-Methylphenoxy)benzoic acid methyl ester is used as an intermediate in the synthesis of Balsalazide (B116300) related compounds. Balsalazide is a medication used to treat mild to moderate ulcerative colitis, a chronic inflammatory bowel disease. The ester's role in the synthesis process is crucial for the development of effective treatments for this condition.

Upstream product

• 67-56-1 methanol 
• 21905-69-1 2-(4-methylphenoxy)-benzoic acid 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 1121-70-6 sodium 4-methylphenoxide 
• 60698-27-3 5-p-tolyloxy-furan-2-carboxylic acid 
• 292638-85-8 acrylic acid methyl ester 
• 106-44-5 p-cresol 
• 118-91-2 ortho-chlorobenzoic acid 
• 19434-35-6 2-(4'-methylphenoxy)benzaldehyde 
• 16497-87-3 potassium o-bromobenzoate 

Downstream Products

• 30087-38-8 methyl 2-[4-(bromomethyl)phenoxy]benzoate 
• 108059-56-9 2-(4-Methyl-2-propionylphenoxy)benzoesaeure-methylester 
• 108059-50-3 2-(2-Acetyl-4-methylphenoxy)benzoesaeure-methylester 
• 108059-57-0 2-(2-Acetyl-4-formylphenoxy)benzoesaeure-methylester 
• 108059-58-1 2-(2-Acetyl-4-carboxyphenoxy)benzoesaeure-methylester 
• 108059-59-2 2-<2-Acetyl-4-(methoxycarbonyl)phenoxy>benzoesaeure-methylester 
• 21905-69-1 2-(4-methylphenoxy)-benzoic acid 
• 607-88-5 p-tolyl 2-hydroxybenzoate 
• 114772-89-3 2-butyl-4-chloro-1-[4-(2-carbomethoxyphenoxy)benzyl]-5-hydroxymethylimidazole 
• 114822-97-8 2-butyl-1-<4-(2-carboxyphenoxy)benzyl>-4-chloro-5-(hydroxymethyl)imidazole 

Relevant academic research and scientific papers

N-Heterocyclic carbene/photo-cocatalyzed oxidative Smiles rearrangement: Synthesis of aryl salicylates from: O -aryl salicylaldehydes

The N-heterocyclic carbene/photo-cocatalyzed oxidative Smiles rearrangement of O-aryl salicylaldehydes was developed. Both electron-deficient and electron-rich aryls worked well as migrating groups, giving the corresponding aryl salicylates in good yields. This reaction features formation of two new C-O bonds and one C-O bond cleavage via metal-free oxidation of the Breslow intermediate using oxygen as the terminal oxidant and following the Smiles rearrangement under photocatalysis.

Nonpeptide Angiotensin II Receptor Antagonist: N-imidazoles and Related Compounds as Potent Antihypertensives

A series of compounds has been synthesized and demonstrated to be antagonists of the angiotensin II (AII) receptor.These compounds are structurally related to the N-(benzamidobenzyl)imidazoles and extend the scope of this new class of nonpeptide AII antag

Dibenzocyclooctene-, Dibenzochalcocine-, and Diarenochalconinediones

2,2'-Oxybis-, -thiobis-, and -methylenebisbenzoic esters 2a-c react with methyllithium in ether to give low yields of 5H-dibenzochalcocine-5,7(6H)-diones 6a, 7a, and dibenzocyclooctene-5,7(6H,12H)-dione (8), respectively.Very good yields of such heterocycles with oxygen (6a-h, 37), sulfur (7a-h, 38) and selenium (36) as key atom are obtained when diaryl ethers (21, 22, 25), -sulfides (27, 29, 30), and -selenides (33) that contain 2'-acetyl- (or -propionyl-) and 2-methoxycarbonyl groups are treated with sodium hydride in boiling toluene.Analogously are prepared the dibenzoxonine-11,13(6H,12H)diones 62a-c and 7H-benzonaphthothionine-7,9-(8H)-dione (65) which are expanded by one ring member.In the analogous reaction of a corresponding benzophenone derivative 35, spiro-3(2H),3'-dione (41) is formed in a tandem reaction. - Under phase transfer conditions the dibenzochalcocinediones 6, 7, 36 and also the corresponding nitrogen cycles 5 react to give mixtures of C- (42-45) and O-alkyl derivatives (46-49).Methyllithium and diisobutylaluminium hydride provide the carbinols 50-54.With bromine and SO2Cl2, respectively, the methylene group is mono- or dihalogenated to the products 56, 57; defined nitration was only possible for the oxacycle 6a.