(2-{Methyl-[2-oxo-1-phenyl-3-(tetrahydro-pyran-2-yloxy)-propyl]-amino}-ethyl)-triphenyl-phosphonium; bromide

Base Information

• Chemical Name: (2-{Methyl-[2-oxo-1-phenyl-3-(tetrahydro-pyran-2-yloxy)-propyl]-amino}-ethyl)-triphenyl-phosphonium; bromide
• CAS No.: 135733-65-2
• Molecular Formula: Br*C₃₅H₃₉NO₃P
• Molecular Weight: 632.577
• Mol file: 135733-65-2.mol

Synonyms:(2-{Methyl-[2-oxo-1-phenyl-3-(tetrahydro-pyran-2-yloxy)-propyl]-amino}-ethyl)-triphenyl-phosphonium; bromide

Chemical Property of (2-{Methyl-[2-oxo-1-phenyl-3-(tetrahydro-pyran-2-yloxy)-propyl]-amino}-ethyl)-triphenyl-phosphonium; bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-{Methyl-[2-oxo-1-phenyl-3-(tetrahydro-pyran-2-yloxy)-propyl]-amino}-ethyl)-triphenyl-phosphonium; bromide

There total 6 articles about (2-{Methyl-[2-oxo-1-phenyl-3-(tetrahydro-pyran-2-yloxy)-propyl]-amino}-ethyl)-triphenyl-phosphonium; bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

<2-(methylamino)ethyl>triphenylphosphonium bromide (34477-69-5) + tetrahydro-2-<(3-bromo-2-oxo-3-phenylpropyl)oxy>pyran (135733-69-6) → (2-{Methyl-[2-oxo-1-phenyl-3-(tetrahydro-pyran-2-yloxy)-propyl]-amino}-ethyl)-triphenyl-phosphonium; bromide (135733-65-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; dichloromethane; for 1h; Ambient temperature;

DOI:10.1021/jo00022a047

Reference yield:

2-bromophenylacetic acid (4870-65-9,31302-84-8) → (2-{Methyl-[2-oxo-1-phenyl-3-(tetrahydro-pyran-2-yloxy)-propyl]-amino}-ethyl)-triphenyl-phosphonium; bromide (135733-65-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 93 percent / thionyl chloride / 48 h / Heating

2: 46 percent / triethylamine / diethyl ether / 1 h / 5 °C

3: trifluoroacetic acid / diethyl ether; H₂O / 1 h / 25 °C

4: 83 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 25 °C

5: 84 percent / triethylamine / CH₂Cl₂; tetrahydrofuran / 1 h / Ambient temperature

With thionyl chloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; water;

DOI:10.1021/jo00022a047

Reference yield:

bromo(phenyl)acetyl chloride (19078-72-9) → (2-{Methyl-[2-oxo-1-phenyl-3-(tetrahydro-pyran-2-yloxy)-propyl]-amino}-ethyl)-triphenyl-phosphonium; bromide (135733-65-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 46 percent / triethylamine / diethyl ether / 1 h / 5 °C

2: trifluoroacetic acid / diethyl ether; H₂O / 1 h / 25 °C

3: 83 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 25 °C

4: 84 percent / triethylamine / CH₂Cl₂; tetrahydrofuran / 1 h / Ambient temperature

With triethylamine; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; water;

DOI:10.1021/jo00022a047

upstream raw materials:

<2-(methylamino)ethyl>triphenylphosphonium bromide

tetrahydro-2-<(3-bromo-2-oxo-3-phenylpropyl)oxy>pyran

2-bromophenylacetic acid

bromo(phenyl)acetyl chloride

Downstream raw materials:

1-methyl-2-phenyl-3-<<((2-propyl)carbamoyl)oxy>methyl>-3-pyrroline

3-(hydroxymethyl)-1-methyl-2-phenyl-3-pyrroline