Technology Process of 2-Hydroxy-4-{2-[2-methyl-3-(naphthalene-1-carbonyl)-indol-1-yl]-ethylamino}-benzoic acid methyl ester
There total 6 articles about 2-Hydroxy-4-{2-[2-methyl-3-(naphthalene-1-carbonyl)-indol-1-yl]-ethylamino}-benzoic acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-Methoxy-4-{2-[2-methyl-3-(naphthalene-1-carbonyl)-indol-1-yl]-ethylamino}-benzoic acid methyl ester;
With
boron tribromide;
In
dichloromethane;
at -78 ℃;
for 2.03333h;
With
water; sodium hydrogencarbonate;
In
dichloromethane;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: methylmagnesium bromide / diethyl ether / 0 - 20 °C
1.2: 1.5 h / 20 °C / Reflux
2.1: sodium hydride; tetrabutylammomium bromide / N,N-dimethyl-formamide; mineral oil / 0.25 h
2.2: 50 °C
3.1: boron tribromide / dichloromethane / 2.03 h / -78 °C
3.2: 20 °C
With
methylmagnesium bromide; tetrabutylammomium bromide; boron tribromide; sodium hydride;
In
diethyl ether; dichloromethane; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogenchloride; water; sodium cyanoborohydride / methanol / 120.03 h / 0 - 20 °C
1.2: pH 7 - 8
2.1: sodium hydride; tetrabutylammomium bromide / N,N-dimethyl-formamide; mineral oil / 0.25 h
2.2: 50 °C
3.1: boron tribromide / dichloromethane / 2.03 h / -78 °C
3.2: 20 °C
With
hydrogenchloride; tetrabutylammomium bromide; water; boron tribromide; sodium hydride; sodium cyanoborohydride;
In
methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;