2-hydroxy-4-{2-[2-methyl-3-(naphthalene-1-carbonyl)-indol-yl]-ethylamino}-benzoic acid

Base Information

Chemical Name:2-hydroxy-4-{2-[2-methyl-3-(naphthalene-1-carbonyl)-indol-yl]-ethylamino}-benzoic acid
CAS No.:1164275-18-6
Molecular Formula:C₂₉H₂₄N₂O₄
Molecular Weight:464.521
Hs Code.:

Synonyms:2-hydroxy-4-{2-[2-methyl-3-(naphthalene-1-carbonyl)-indol-yl]-ethylamino}-benzoic acid

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Chemical Property of 2-hydroxy-4-{2-[2-methyl-3-(naphthalene-1-carbonyl)-indol-yl]-ethylamino}-benzoic acid

Chemical Property:

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Technology Process of 2-hydroxy-4-{2-[2-methyl-3-(naphthalene-1-carbonyl)-indol-yl]-ethylamino}-benzoic acid

There total 7 articles about 2-hydroxy-4-{2-[2-methyl-3-(naphthalene-1-carbonyl)-indol-yl]-ethylamino}-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1164275-26-6
2-Hydroxy-4-{2-[2-methyl-3-(naphthalene-1-carbonyl)-indol-1-yl]-ethylamino}-benzoic acid methyl ester

: 1164275-18-6
2-hydroxy-4-{2-[2-methyl-3-(naphthalene-1-carbonyl)-indol-yl]-ethylamino}-benzoic acid

Guidance literature:: 2-Hydroxy-4-{2-[2-methyl-3-(naphthalene-1-carbonyl)-indol-1-yl]-ethylamino}-benzoic acid methyl ester; With water; sodium hydroxide; In methanol; Reflux;

With hydrogenchloride; In methanol; water; pH=7;

Reference yield:

: 95-20-5
2-methyl-1H-indole

: 1164275-18-6
2-hydroxy-4-{2-[2-methyl-3-(naphthalene-1-carbonyl)-indol-yl]-ethylamino}-benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: methylmagnesium bromide / diethyl ether / 0 - 20 °C

1.2: 1.5 h / 20 °C / Reflux

2.1: sodium hydride; tetrabutylammomium bromide / N,N-dimethyl-formamide; mineral oil / 0.25 h

2.2: 50 °C

3.1: boron tribromide / dichloromethane / 2.03 h / -78 °C

3.2: 20 °C

4.1: sodium hydroxide; water / methanol / Reflux

4.2: pH 7

With methylmagnesium bromide; tetrabutylammomium bromide; water; boron tribromide; sodium hydride; sodium hydroxide; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1164275-24-4
4-(2-Chloro-ethylamino)-2-methoxy-benzoic acid methyl ester

: 1164275-18-6
2-hydroxy-4-{2-[2-methyl-3-(naphthalene-1-carbonyl)-indol-yl]-ethylamino}-benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride; tetrabutylammomium bromide / N,N-dimethyl-formamide; mineral oil / 0.25 h

1.2: 50 °C

2.1: boron tribromide / dichloromethane / 2.03 h / -78 °C

2.2: 20 °C

3.1: sodium hydroxide; water / methanol / Reflux

3.2: pH 7

With tetrabutylammomium bromide; water; boron tribromide; sodium hydride; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;