(4R,6S)-4-(3-Butynyl)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepine

Base Information

Chemical Name:(4R,6S)-4-(3-Butynyl)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepine
CAS No.:937058-06-5
Molecular Formula:C₂₄H₂₂ClNO₃
Molecular Weight:407.897
Hs Code.:

Synonyms:(4R,6S)-4-(3-Butynyl)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepine

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Chemical Property of (4R,6S)-4-(3-Butynyl)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepine

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Technology Process of (4R,6S)-4-(3-Butynyl)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepine

There total 9 articles about (4R,6S)-4-(3-Butynyl)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl methanesulfonate

: 1216963-74-4
lithium acetylide-ethylenediamine complex

: 937058-06-5
(4R,6S)-4-(3-Butynyl)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepine

Guidance literature:: 2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl methanesulfonate; lithium acetylide-ethylenediamine complex; tetra-(n-butyl)ammonium iodide; In dimethyl sulfoxide; at 20 ℃;

With water; In dimethyl sulfoxide; at 0 ℃; for 0.0833333h;

Reference yield:

: 937057-48-2
[5-chloro-2-(1H-pyrrol-1-yl)phenyl](2,3-dimethoxyphenyl)methanone

: 937058-06-5
(4R,6S)-4-(3-Butynyl)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepine

Guidance literature:: Multi-step reaction with 8 steps

1.1: trichlorophosphate / 0.17 h / 0 - 20 °C

1.2: 2 h / 50 °C / Heating / reflux

1.3: 0.5 h / Heating / reflux

2.1: toluene / 100 °C

3.1: sodium tetrahydroborate / methanol / 1 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 20 °C

5.1: Resolution of racemate

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

6.2: 3 h / 0 °C

7.1: triethylamine / dichloromethane / 3 h / 0 °C

8.1: tetra-(n-butyl)ammonium iodide / dimethyl sulfoxide / 20 °C

8.2: 0.08 h / 0 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; triethylamine; trifluoroacetic acid; trichlorophosphate; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; toluene;

Reference yield:

: 937054-13-2
methyl 2-[8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetate

: 937058-06-5
(4R,6S)-4-(3-Butynyl)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepine

Guidance literature:: Multi-step reaction with 4 steps

1.1: Resolution of racemate

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

2.2: 3 h / 0 °C

3.1: triethylamine / dichloromethane / 3 h / 0 °C

4.1: tetra-(n-butyl)ammonium iodide / dimethyl sulfoxide / 20 °C

4.2: 0.08 h / 0 °C

With lithium aluminium tetrahydride; triethylamine; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;