cis-1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-2-piperidinemethanol

Base Information

Chemical Name:cis-1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-2-piperidinemethanol
CAS No.:138155-19-8
Molecular Formula:C₁₉H₂₆Cl₂N₂O₂
Molecular Weight:385.334
Hs Code.:

Synonyms:cis-1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-2-piperidinemethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of cis-1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-2-piperidinemethanol

Chemical Property:

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Technology Process of cis-1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-2-piperidinemethanol

There total 5 articles about cis-1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-2-piperidinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 125104-88-3,138155-17-6,138155-18-7
cis-methyl 1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-2-piperidinecarboxylate

: 138155-19-8
cis-1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-2-piperidinemethanol

Guidance literature:: With sodium tetrahydroborate; In methanol; tert-butyl alcohol; for 16h; Heating;
DOI:10.1021/jm00081a009

Reference yield:

: 13602-11-4
6-methylpicolinic acid methyl ester

: 138155-19-8
cis-1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-2-piperidinemethanol

Guidance literature:: Multi-step reaction with 5 steps

1: NBS, (PhCO₂)2 / CCl₄ / 24 h / Irradiation

2: CCl₄; CH₂Cl₂ / Ambient temperature

3: 49 percent / H₂, AcOH / PtO₂ / 4 h / 760 Torr / Ambient temperature

4: 1.) 1,1'-carbonyldiimidazole / 1.) CH₂Cl₂, RT, 1.5 h, 2.) CH₂Cl₂, RT, 72 h

5: 22 percent / NaBH₄ / 2-methyl-propan-2-ol; methanol / 16 h / Heating

With sodium tetrahydroborate; N-Bromosuccinimide; hydrogen; acetic acid; 1,1'-carbonyldiimidazole; dibenzoyl peroxide; platinum(IV) oxide; In methanol; tetrachloromethane; dichloromethane; tert-butyl alcohol;
DOI:10.1021/jm00081a009

Reference yield:

: 146462-25-1
methyl 6-(bromomethyl)picolinate

: 138155-19-8
cis-1-<(3,4-dichlorophenyl)acetyl>-6-(1-pyrrolidinylmethyl)-2-piperidinemethanol

Guidance literature:: Multi-step reaction with 4 steps

1: CCl₄; CH₂Cl₂ / Ambient temperature

2: 49 percent / H₂, AcOH / PtO₂ / 4 h / 760 Torr / Ambient temperature

3: 1.) 1,1'-carbonyldiimidazole / 1.) CH₂Cl₂, RT, 1.5 h, 2.) CH₂Cl₂, RT, 72 h

4: 22 percent / NaBH₄ / 2-methyl-propan-2-ol; methanol / 16 h / Heating

With sodium tetrahydroborate; hydrogen; acetic acid; 1,1'-carbonyldiimidazole; platinum(IV) oxide; In methanol; tetrachloromethane; dichloromethane; tert-butyl alcohol;
DOI:10.1021/jm00081a009