ethyl 4-(3-[(5-(3-[5-(ethoxycarbonyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4-pyrimidinyl]phenoxy)pentyl)oxy]phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

Base Information

• Chemical Name: ethyl 4-(3-[(5-(3-[5-(ethoxycarbonyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4-pyrimidinyl]phenoxy)pentyl)oxy]phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
• CAS No.: 1315247-95-0
• Molecular Formula: C₃₃H₄₀N₄O₆S₂
• Molecular Weight: 652.836
• Mol file: 1315247-95-0.mol

Synonyms:ethyl 4-(3-[(5-(3-[5-(ethoxycarbonyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4-pyrimidinyl]phenoxy)pentyl)oxy]phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

Chemical Property of ethyl 4-(3-[(5-(3-[5-(ethoxycarbonyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4-pyrimidinyl]phenoxy)pentyl)oxy]phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4-(3-[(5-(3-[5-(ethoxycarbonyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4-pyrimidinyl]phenoxy)pentyl)oxy]phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

There total 3 articles about ethyl 4-(3-[(5-(3-[5-(ethoxycarbonyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4-pyrimidinyl]phenoxy)pentyl)oxy]phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3,3'-[pentane-1,5-diylbis(oxy)]dibenzaldehyde (110047-92-2) + ethyl acetoacetate (141-97-9) + thiourea (17356-08-0) → ethyl 4-(3-[(5-(3-[5-(ethoxycarbonyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4-pyrimidinyl]phenoxy)pentyl)oxy]phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate (1315247-95-0)

Guidance literature:

With cerium(III) chloride heptahydrate; In acetonitrile; at 85 - 90 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2011.04.048

Reference yield:

1,5-dibromo-pentane (111-24-0) → ethyl 4-(3-[(5-(3-[5-(ethoxycarbonyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4-pyrimidinyl]phenoxy)pentyl)oxy]phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate (1315247-95-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; potassium iodide / acetonitrile / 48 h / 90 °C

2: cerium(III) chloride heptahydrate / acetonitrile / 85 - 90 °C / Inert atmosphere

With cerium(III) chloride heptahydrate; potassium carbonate; potassium iodide; In acetonitrile; 2: Biginelli pyrimidine synthesis;

DOI:10.1016/j.ejmech.2011.04.048

Reference yield:

meta-hydroxybenzaldehyde (100-83-4) → ethyl 4-(3-[(5-(3-[5-(ethoxycarbonyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4-pyrimidinyl]phenoxy)pentyl)oxy]phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate (1315247-95-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; potassium iodide / acetonitrile / 48 h / 90 °C

2: cerium(III) chloride heptahydrate / acetonitrile / 85 - 90 °C / Inert atmosphere

With cerium(III) chloride heptahydrate; potassium carbonate; potassium iodide; In acetonitrile; 2: Biginelli pyrimidine synthesis;

DOI:10.1016/j.ejmech.2011.04.048

upstream raw materials:

1,5-dibromo-pentane

3,3'-[pentane-1,5-diylbis(oxy)]dibenzaldehyde

ethyl acetoacetate

thiourea