110047-92-2Relevant academic research and scientific papers
Novel bisbenzimidazoles with antileishmanial effectiveness
Mayence, Annie,Pietka, Aurelie,Collins, Margaret S.,Cushion, Melanie T.,Tekwani, Babu L.,Huang, Tien L.,Vanden Eynde, Jean Jacques
, p. 2658 - 2661 (2008)
A small library of 2,2′-[(α,ω-alkanediylbis(oxyphenylene)]bis-1H-benzimidazoles has been prepared and screened in vitro against Pneumocystis carinii, Trypanosoma brucei rhodesiense, and Leishmania donovani. Among the six tested compounds two derivatives e
Overcoming Strain-Induced Rearrangement Reactions: A Mild Dehydrative Aromatization Protocol for Synthesis of Highly Distorted p-Phenylenes
Mitra, Nirmal K.,Meudom, Rolande,Corzo, Hector H.,Gorden, John D.,Merner, Bradley L.
, p. 3235 - 3240 (2016)
A series of p-terphenyl-based macrocycles, containing highly distorted p-phenylene units, have been synthesized. Biaryl bonds of the nonplanar p-terphenyl nuclei were constructed in the absence of Pd-catalyzed or Ni-mediated cross-coupling reactions, usin
A non-cross-coupling approach to arene-bridged macrocycles: Synthesis, structure, and direct, regioselective functionalization of a cycloparaphenylene fragment
Mitra, Nirmal K.,Meudom, Rolande,Gorden, John D.,Merner, Bradley L.
, p. 2700 - 2703 (2015)
A new synthetic strategy that employs a relatively unstrained, 1,4-diketo-bridged macrocycle as a precursor to a strained, 1,4-arene-bridged (bent para-phenylene) macrocycle has been developed. The distorted p-terphenyl nucleus (CPP fragment) of the macro
Design, two-directional synthesis, DFT study of new pyrimido[5,4-d]pyrimidine-2,8-dione derivatives
Sheykhi-Estalkhjani, Ammar,Mahmoodi, Nosrat O.,Yahyazadeh, Asieh,Pasandideh Nadamani, Meysam,Taherpour Nahzomi, Hossein
, p. 749 - 756 (2019)
A facile two-directional synthesis of new pyrimido[5,4-d]pyrimidine-2,8-dione was reported via an efficient reaction of premade bis-aldehydes and 1-(2-amino-1,2-dicyanovinyl)-3-phenylurea in the presence of triethylamine as the base and Cu (II) as catalys
One-pot synthesis of bis(4,5-diphenylimidazol-2-yl-phenyl)glycols and evaluation of their antimicrobial activity
Linga Goud,Ramesh,Ashok,Prabhakar Reddy
, p. 673 - 678 (2015)
Abstract A new series of bis(4,5-diphenylimidazol-2-yl-phenyl)glycols were synthesized by reaction of bis(formylphenyl)glycols with benzil/benzoin and ammonium acetate in presence of iodine/acetic acid in ethanol. All newly synthesized compounds were char
Synthesis, Antimicrobial Evaluations, and DNA Photo Cleavage Studies of New Bispyranopyrazoles
Yusuf, Mohamad,Kaur, Manvinder,Sohal, Harvinder Singh
, p. 706 - 713 (2017/02/05)
The bispyranopyrazoles (4a, 4b, 4c, 4d, 4e, 4f, 4g) were synthesized from the reactions of dibenzaldehydes (2a, 2b, 2c, 2d, 2e, 2f, 2g) with 3-methylpyrazole-5-one 3 and malononitrile by refluxing under alcoholic medium. The dibenzaldehydes were obtained from the O-alkylation of 3-hydroxybenzaldehyde with suitable 1,ω-dibromoalkanes under the alkaline conditions in the presence of dry EtOH/DMF. The structures of bisheterocyclics were determined from rigorous analysis of their spectral parameters (IR,1H-NMR,13C-NMR, and ESI-MS). The newly prepared compounds were screened for their antimicrobial activity against seven bacterial and five fungal strains. The DNA photo cleavage potential of these compounds was also evaluated by using agarose gel electrophoresis, and bispyranopyrazoles 4b, 4d and 4e exhibited significant level of DNA photocleavage activity.
Phenol-yne Click Polymerization: An Efficient Technique to Facilely Access Regio- and Stereoregular Poly(vinylene ether ketone)s
Shi, Yang,Bai, Tianwen,Bai, Wei,Wang, Zhe,Chen, Ming,Yao, Bicheng,Sun, Jing Zhi,Qin, Anjun,Ling, Jun,Tang, Ben Zhong
supporting information, p. 10725 - 10731 (2017/08/21)
Alkyne-based click polymerizations have been well-established. However, in order to expand the family to synthesize polymers with new structures and novel properties, new types of click polymerizations are highly demanded. In this study, for the first tim
Biological evaluation of bisbenzaldehydes against four Mycobacterium species
Cappoen, Davie,Forge, Delphine,Vercammen, Frank,Mathys, Vanessa,Kiass, Mehdi,Roupie, Virginie,Anthonissen, Roel,Verschaeve, Luc,Vanden Eynde, Jean Jacques,Huygen, Kris
, p. 731 - 738 (2013/07/25)
A series of bisbenzaldehydes and structurally related analogs, conveniently synthesized via microwave-assisted reactions, were evaluated in vitro against drug susceptible and multi-drug resistant Mycobacterium tuberculosis, against virulent Mycobacterium bovis, against Mycobacterium ulcerans and against two Mycobacterium avium subspecies. Among the 33 substances that were tested, compound 12, i.e. 4,4′-[1,12-dodecanediyl(oxy)]bisbenzaldehyde, emerged as the most promising hit. Its activity was further confirmed in an intracellular growth inhibition assay of M. tb in murine J774 A.1 macrophages. None of the compounds showed significant cytotoxicity on human C3A hepatocytes in a neutral red dye uptake assay and no genotoxicity or mutagenicity was observed as demonstrated by a VITOTOX test and confirmed with a comet assay.
New 1,3,4-bisthiadiazolines: Synthesis, characterization and antimicrobial evaluations
Yusuf, Mohamad,Kaur, Manvinder,Jain, Payal,Solanki, Indu
, p. 470 - 478,9 (2012/12/11)
The bisthiadiazolines 4a-4g have been synthesized in good yields from the cyclization reactions of bisthiosemicarbazones 3a-3g with acetic anhydride. The condensation reaction of dibenzaldehydes 2a-2g with thiosemicarbazide in alcoholic medium provided 3a
Bis(oxyphenylene)benzimidazoles: A novel class of anti-Plasmodium falciparum agents
Mayence, Annie,Vanden Eynde, Jean Jacques,Kaiser, Marcel,Brun, Reto,Yarlett, Nigel,Huang, Tien L.
experimental part, p. 7493 - 7500 (2012/01/03)
A small library of 26 2,2′-[alkane-α,ω- diylbis(oxyphenylene)]bis-1H-benzimidazoles has been prepared and evaluated against Giardia intestinalis, Entamoeba histolytica, Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium
