2-[2-(3-{[2-(2-amino-2-oxoethoxy)acetamido]methyl}benzylamino)-2-oxoethoxy]-N,N-dioctylacetamide

Base Information

• Chemical Name: 2-[2-(3-{[2-(2-amino-2-oxoethoxy)acetamido]methyl}benzylamino)-2-oxoethoxy]-N,N-dioctylacetamide
• CAS No.: 1325217-47-7
• Molecular Formula: C₃₂H₅₄N₄O₆
• Molecular Weight: 590.804
• Mol file: 1325217-47-7.mol

Synonyms:2-[2-(3-{[2-(2-amino-2-oxoethoxy)acetamido]methyl}benzylamino)-2-oxoethoxy]-N,N-dioctylacetamide

Chemical Property of 2-[2-(3-{[2-(2-amino-2-oxoethoxy)acetamido]methyl}benzylamino)-2-oxoethoxy]-N,N-dioctylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-(3-{[2-(2-amino-2-oxoethoxy)acetamido]methyl}benzylamino)-2-oxoethoxy]-N,N-dioctylacetamide

There total 5 articles about 2-[2-(3-{[2-(2-amino-2-oxoethoxy)acetamido]methyl}benzylamino)-2-oxoethoxy]-N,N-dioctylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-(2-amino-2-oxoethoxy)acetic acid (22064-40-0) + 2-{2-[3-(aminomethyl)benzylamino]-2-oxoethoxy}-N,N-dioctylethanamide (1325217-51-3) → 2-[2-(3-{[2-(2-amino-2-oxoethoxy)acetamido]methyl}benzylamino)-2-oxoethoxy]-N,N-dioctylacetamide (1325217-47-7)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 72h; Inert atmosphere;

DOI:10.1002/ejoc.201100443

Reference yield:

2-dioctylcarbamoylmethoxy-N-[3-[(2-dioctyl-carbamoylmethoxy-acetylamino)methyl]benzyl]acetamide (1027755-54-9) → 2-[2-(3-{[2-(2-amino-2-oxoethoxy)acetamido]methyl}benzylamino)-2-oxoethoxy]-N,N-dioctylacetamide (1325217-47-7)

Guidance literature:

Multi-step reaction with 2 steps

1: dodecane; octanol / Irradiation

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 72 h / 20 °C / Inert atmosphere

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dodecane; octanol; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201100443

Reference yield:

1-(N-Boc-aminomethyl)-3-(aminomethyl)benzene (108467-99-8) → 2-[2-(3-{[2-(2-amino-2-oxoethoxy)acetamido]methyl}benzylamino)-2-oxoethoxy]-N,N-dioctylacetamide (1325217-47-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 72 h / 20 °C / Inert atmosphere

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201100443

upstream raw materials:

2-dioctylcarbamoylmethoxy-N-[3-[(2-dioctyl-carbamoylmethoxy-acetylamino)methyl]benzyl]acetamide

2-(2-amino-2-oxoethoxy)acetic acid

2-{2-[3-(aminomethyl)benzylamino]-2-oxoethoxy}-N,N-dioctylethanamide

tert-butyl 3-({2-[2-(dioctylamino)-2-oxoethoxy]acetamido}methyl)benzylcarbamate

Refernces