-2-spiro-5'-(4'-amino-1',2'-oxathiole-2',2'-dioxide)

Base Information

Chemical Name:-2-spiro-5'-(4'-amino-1',2'-oxathiole-2',2'-dioxide)
CAS No.:136904-68-2
Molecular Formula:C₂₂H₃₃NO₈SSi
Molecular Weight:499.657
Hs Code.:

<methyl 4,6-O-benzylidene-3-O-(tert-butyldimethylsilyl)-α-D-glucopyranoside>-2-spiro-5'-(4'-amino-1',2'-oxathiole-2',2'-dioxide)

Synonyms:-2-spiro-5'-(4'-amino-1',2'-oxathiole-2',2'-dioxide)

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Chemical Property of -2-spiro-5'-(4'-amino-1',2'-oxathiole-2',2'-dioxide)

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Technology Process of -2-spiro-5'-(4'-amino-1',2'-oxathiole-2',2'-dioxide)

There total 6 articles about -2-spiro-5'-(4'-amino-1',2'-oxathiole-2',2'-dioxide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 136919-89-6
methyl 4,6-O-benzylidene-3-O-(tert-butyldimethylsilyl)-2-C-cyano-2-O-mesyl-α-D-glucopyranoside

: 136904-68-2
-2-spiro-5'-(4'-amino-1',2'-oxathiole-2',2'-dioxide)

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; for 3h; Ambient temperature;
DOI:10.1016/0008-6215(92)84176-S

Reference yield:

: 112711-35-0
methyl 3-O-[(1,1-dimethylethyl)dimethylsilyl]-4,6-O-[(R)-phenylmethylene]-α-D-glucopyranoside

: 136904-68-2
-2-spiro-5'-(4'-amino-1',2'-oxathiole-2',2'-dioxide)

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / pyridine, CrO₃, Ac₂O / CH₂Cl₂ / 0.25 h / Ambient temperature

2: NaHCO₃ / H₂O; diethyl ether / 24 h / Ambient temperature

3: pyridine / 8 - 10 °C

4: 73 percent / DBU / acetonitrile / 3 h / Ambient temperature

With pyridine; chromium(VI) oxide; acetic anhydride; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In diethyl ether; dichloromethane; water; acetonitrile;
DOI:10.1016/0008-6215(92)84176-S

Reference yield:

: 78342-32-2
Methyl 4,6-O-benzylidene-3-O-(t-butyldimethylsilyl)-α-D-ribo-hexopyranosid-2-uloside

: 136904-68-2
-2-spiro-5'-(4'-amino-1',2'-oxathiole-2',2'-dioxide)

Guidance literature:: Multi-step reaction with 3 steps

1: NaHCO₃ / H₂O; diethyl ether / 24 h / Ambient temperature

2: pyridine / 8 - 10 °C

3: 73 percent / DBU / acetonitrile / 3 h / Ambient temperature

With pyridine; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In diethyl ether; water; acetonitrile;
DOI:10.1016/0008-6215(92)84176-S