3,4-Pyrrolidinediol, 1-chloro-, 3,4-dibenzoate, (3S,4S)-

Base Information

Chemical Name:3,4-Pyrrolidinediol, 1-chloro-, 3,4-dibenzoate, (3S,4S)-
CAS No.:138228-48-5
Molecular Formula:C₁₈H₁₆ClNO₄
Molecular Weight:345.782
Hs Code.:
DSSTox Substance ID:DTXSID001200548

Synonyms:3,4-Pyrrolidinediol, 1-chloro-, 3,4-dibenzoate, (3S,4S)-;DTXSID001200548;138228-48-5

Suppliers and Price of 3,4-Pyrrolidinediol, 1-chloro-, 3,4-dibenzoate, (3S,4S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,4-Pyrrolidinediol, 1-chloro-, 3,4-dibenzoate, (3S,4S)-

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:345.0767857
Heavy Atom Count:24
Complexity:406

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C(C(CN1Cl)OC(=O)C2=CC=CC=C2)OC(=O)C3=CC=CC=C3
Isomeric SMILES:C1[C@@H]([C@H](CN1Cl)OC(=O)C2=CC=CC=C2)OC(=O)C3=CC=CC=C3

Technology Process of 3,4-Pyrrolidinediol, 1-chloro-, 3,4-dibenzoate, (3S,4S)-

There total 3 articles about 3,4-Pyrrolidinediol, 1-chloro-, 3,4-dibenzoate, (3S,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 138228-46-3
(3S,4S)-4-(benzoyloxy)pyrrolidin-3-yl benzoate

: 138228-48-5
(3S,4S)-3,4-dibenzoyloxy-1-chloropyrrolidine

Guidance literature:: With N-chloro-succinimide; In diethyl ether; for 2h; Ambient temperature;
DOI:10.1248/cpb.39.2219

Reference yield:

: 98-88-4
benzoyl chloride

: 138228-48-5
(3S,4S)-3,4-dibenzoyloxy-1-chloropyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / Na₂CO₃ / CH₂Cl₂; H₂O / 2 h / Ambient temperature

2: 1.) AcOH, H₂, 2.) aq. KOH / 1.) 20percent Pd(OH)2/C / 1.) 4 atm, 24 h, 2.) methanol

3: 91 percent / N-chlorosuccinimide / diethyl ether / 2 h / Ambient temperature

With potassium hydroxide; N-chloro-succinimide; hydrogen; sodium carbonate; acetic acid; palladium dihydroxide; In diethyl ether; dichloromethane; water;
DOI:10.1248/cpb.39.2219

Reference yield:

: 138228-44-1
(3S,4S)-3,4-dibenzoyloxy-1-benzylpyrrolidine

: 138228-48-5
(3S,4S)-3,4-dibenzoyloxy-1-chloropyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) AcOH, H₂, 2.) aq. KOH / 1.) 20percent Pd(OH)2/C / 1.) 4 atm, 24 h, 2.) methanol

2: 91 percent / N-chlorosuccinimide / diethyl ether / 2 h / Ambient temperature

With potassium hydroxide; N-chloro-succinimide; hydrogen; acetic acid; palladium dihydroxide; In diethyl ether;
DOI:10.1248/cpb.39.2219