2-methoxy-5-[2-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-benzoic acid benzyl ester

Base Information

Chemical Name:2-methoxy-5-[2-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-benzoic acid benzyl ester
CAS No.:377777-86-1
Molecular Formula:C₂₀H₁₉Cl₃O₅
Molecular Weight:445.727
Hs Code.:

Synonyms:2-methoxy-5-[2-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-benzoic acid benzyl ester

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Chemical Property of 2-methoxy-5-[2-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-benzoic acid benzyl ester

Chemical Property:

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Technology Process of 2-methoxy-5-[2-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-benzoic acid benzyl ester

There total 4 articles about 2-methoxy-5-[2-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-benzoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: 2-methoxy-5-[2-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-benzoic acid

: 377777-86-1
2-methoxy-5-[2-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-benzoic acid benzyl ester

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 60 ℃; for 16h;
DOI:10.1016/S0040-4039(01)01515-5

Reference yield:

: 1929-29-9
3-(4-methoxyphenyl)propanoic acid

: 377777-86-1
2-methoxy-5-[2-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-benzoic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / DCC; DMAP / CH₂Cl₂ / 21 h / 23 °C

2: 100 percent / SnCl₄ / CH₂Cl₂ / 2 h

3: KMnO₄ / acetone; H₂O / 5 h / 50 °C

4: n-Bu₄NI; NaHCO₃ / dimethylformamide / 16 h / 60 °C

With dmap; potassium permanganate; tin(IV) chloride; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4039(01)01515-5

Reference yield:

: 377777-84-9
3-(4-methoxy-phenyl)-propionic acid 2,2,2-trichloro-ethyl ester

: 377777-86-1
2-methoxy-5-[2-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-benzoic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / SnCl₄ / CH₂Cl₂ / 2 h

2: KMnO₄ / acetone; H₂O / 5 h / 50 °C

3: n-Bu₄NI; NaHCO₃ / dimethylformamide / 16 h / 60 °C

4: 82 percent / Zn; AcOH / 6 h / 0 - 23 °C

With potassium permanganate; tin(IV) chloride; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; acetic acid; zinc; In dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4039(01)01515-5